细胞自噬的机制与后果。
Mechanisms and consequences of entosis.
作者信息
Krishna Shefali, Overholtzer Michael
机构信息
Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
出版信息
Cell Mol Life Sci. 2016 Jun;73(11-12):2379-86. doi: 10.1007/s00018-016-2207-0. Epub 2016 Apr 5.
Abstract
Multiple mechanisms have emerged where the engulfment of whole live cells, leading to the formation of what are called 'cell-in-cell' structures, induces cell death. Entosis is one such mechanism that drives cell-in-cell formation during carcinogenesis and development. Curiously, entotic cells participate actively in their own engulfment, by invading into their hosts, and are then killed non-cell-autonomously. Here we review the mechanisms of entosis and entotic cell death and the consequences of entosis on cell populations.
摘要
多种机制已经出现，其中整个活细胞的吞噬作用会导致所谓的“细胞中细胞”结构的形成，进而诱导细胞死亡。细胞内吞作用就是这样一种机制，它在癌症发生和发育过程中驱动“细胞中细胞”结构的形成。奇怪的是，内吞细胞通过侵入宿主细胞而积极参与自身的吞噬过程，然后被非细胞自主地杀死。在这里，我们综述了细胞内吞作用和内吞细胞死亡的机制以及细胞内吞作用对细胞群体的影响。
相似文献
1
Mechanisms and consequences of entosis.
Cell Mol Life Sci. 2016 Jun;73(11-12):2379-86. doi: 10.1007/s00018-016-2207-0. Epub 2016 Apr 5.
2
Entosis: Cell-in-Cell Formation that Kills Through Entotic Cell Death.
Curr Mol Med. 2015;15(9):861-6. doi: 10.2174/1566524015666151026100042.
3
Autophagy proteins regulate cell engulfment mechanisms that participate in cancer.
Semin Cancer Biol. 2013 Oct;23(5):329-36. doi: 10.1016/j.semcancer.2013.05.004. Epub 2013 May 30.
4
Methods for the Study of Entotic Cell Death.
Methods Mol Biol. 2019;1880:447-454. doi: 10.1007/978-1-4939-8873-0_28.
5
Orai1 is an Entotic Ca Channel for Non-Apoptotic Cell Death, Entosis in Cancer Development.
Adv Sci (Weinh). 2023 May;10(14):e2205913. doi: 10.1002/advs.202205913. Epub 2023 Mar 24.
6
Amino acids and mechanistic target of rapamycin regulate the fate of live engulfed cells.
FASEB J. 2021 Oct;35(10):e21909. doi: 10.1096/fj.202100870R.
7
Cell-in-cell structures are involved in the competition between cells in human tumors.
Mol Cell Oncol. 2015 Jan 23;2(4):e1002707. doi: 10.1080/23723556.2014.1002707. eCollection 2015 Oct-Dec.
8
Mechanisms and significance of entosis for tumour growth and progression.
Cell Death Discov. 2024 Mar 1;10(1):109. doi: 10.1038/s41420-024-01877-9.
9
Methods for the study of entosis.
Methods Mol Biol. 2013;1004:59-66. doi: 10.1007/978-1-62703-383-1_5.
10
Entosis: The emerging face of non-cell-autonomous type IV programmed death.
Biomed J. 2017 Jun;40(3):133-140. doi: 10.1016/j.bj.2017.05.001. Epub 2017 May 31.
引用本文的文献
1
Comprehensive analysis of regulated cell death pathways: intrinsic disorder, protein-protein interactions, and cross-pathway communication.
Apoptosis. 2025 Aug 19. doi: 10.1007/s10495-025-02161-6.
2
Comprehensive landscape of cell death mechanisms: from molecular cross-talk to therapeutic innovation in oncology.
Front Cell Dev Biol. 2025 Jul 16;13:1611055. doi: 10.3389/fcell.2025.1611055. eCollection 2025.
3
Integrated transcriptomic and immune profiling reveals crucial molecular pathways and hub genes associated with postoperative delirium in elderly patients.
Front Med (Lausanne). 2025 May 9;12:1580355. doi: 10.3389/fmed.2025.1580355. eCollection 2025.
4
The inducible role of autophagy in cell death: emerging evidence and future perspectives.
Cell Commun Signal. 2025 Mar 26;23(1):151. doi: 10.1186/s12964-025-02135-w.
5
Exploring cell death pathways in oral cancer: mechanisms, therapeutic strategies, and future perspectives.
Discov Oncol. 2025 Mar 26;16(1):395. doi: 10.1007/s12672-025-02022-3.
6
Role of oxeiptosis in disease mechanisms and therapeutic opportunities.
Apoptosis. 2025 Mar 10. doi: 10.1007/s10495-025-02087-z.
7
Neutrophil Engulfment in Cancer: Friend or Foe?
Cancers (Basel). 2025 Jan 24;17(3):384. doi: 10.3390/cancers17030384.
8
Identification of the entosis-related prognostic signature and tumour microenvironment in hepatocellular carcinoma on the basis of bioinformatics analysis and experimental validation.
Clin Exp Med. 2025 Feb 12;25(1):55. doi: 10.1007/s10238-025-01580-8.
9
A bibliometric and visualization analysis of entosis research from 2007 to 2024.
Front Oncol. 2024 Oct 28;14:1424100. doi: 10.3389/fonc.2024.1424100. eCollection 2024.
10
Sphingolipid metabolism and regulated cell death in malignant melanoma.
Apoptosis. 2024 Dec;29(11-12):1860-1878. doi: 10.1007/s10495-024-02002-y. Epub 2024 Jul 28.
本文引用的文献
1
Cell-in-cell phenomenon: A New Paradigm in Life Sciences.
Curr Mol Med. 2015;15(9):810-8. doi: 10.2174/1566524015666151026095730.
2
Entosis: Cell-in-Cell Formation that Kills Through Entotic Cell Death.
Curr Mol Med. 2015;15(9):861-6. doi: 10.2174/1566524015666151026100042.
3
Entosis and Related Forms of Cell Death within Cells.
Curr Mol Med. 2015;15(9):805-9. doi: 10.2174/1566524015666151026100339.
4
Cancer Cell Cannibalism: A Primeval Option to Survive.
Curr Mol Med. 2015;15(9):836-41. doi: 10.2174/1566524015666151026100916.
5
Mammalian Cell Competitions, Cell-in-Cell Phenomena and Their Biomedical Implications.
Curr Mol Med. 2015;15(9):852-60. doi: 10.2174/1566524015666151026101101.
6
Suicidal emperipolesis: a process leading to cell-in-cell structures, T cell clearance and immune homeostasis.
Curr Mol Med. 2015;15(9):819-27. doi: 10.2174/1566524015666151026102143.
7
Phagoptosis - Cell Death By Phagocytosis - Plays Central Roles in Physiology, Host Defense and Pathology.
Curr Mol Med. 2015;15(9):842-51. doi: 10.2174/156652401509151105130628.
8
Cell-in-Cell: A Century-Old Mystery Comes to the Table.
Curr Mol Med. 2015;15(9):802-4. doi: 10.2174/1566524015999151026143028.
9
Prognostic Value of Homotypic Cell Internalization by Nonprofessional Phagocytic Cancer Cells.
Biomed Res Int. 2015;2015:359392. doi: 10.1155/2015/359392. Epub 2015 Oct 4.
10
Impaired formation of homotypic cell-in-cell structures in human tumor cells lacking alpha-catenin expression.
Sci Rep. 2015 Jul 20;5:12223. doi: 10.1038/srep12223.
Zotero 插件