Yuan H, Yao Y S, Chen G M, Sheng J, Xu L, Pan H F
Department of Preventive Medicine, Wannan Medical College, Wuhu, Anhui, China.
School of Health Management, Anhui Medical University, Hefei, Anhui, China.
J Biol Regul Homeost Agents. 2016 Jan-Mar;30(1):123-9.
This study aims to investigate the serum T-cell immunoglobulin mucin (TIM)-1 and TIM-3 levels in systemic lupus erythematosus (SLE) patients and analyze their correlations with clinical features. Sixtyone SLE patients and 69 healthy controls were enrolled, serum TIM-1 and TIM-3 levels were detected by ELISA. Results demonstrated that both serum TIM-1 and TIM-3 levels were significantly decreased in SLE patients compared with controls (both P less than 0.05). Lower serum TIM-3 levels in SLE patients with nephritis were observed when compared to those without nephritis, with a marginal statistical significance (P=0.059). However, both serum TIM-1 and TIM-3 levels had no significant correlation with SLE disease activity (both >0.05). In summary, decreased serum TIM-1 and TIM-3 levels and association of TIM-3 with nephritis suggest their possible role in the development and pathogenesis of SLE. However, further studies are needed to confirm these preliminary results.
本研究旨在调查系统性红斑狼疮（SLE）患者血清T细胞免疫球蛋白黏蛋白（TIM）-1和TIM-3水平，并分析其与临床特征的相关性。纳入61例SLE患者和69例健康对照，采用酶联免疫吸附测定（ELISA）法检测血清TIM-1和TIM-3水平。结果显示，与对照组相比，SLE患者血清TIM-1和TIM-3水平均显著降低（均P<0.05）。与无肾炎的SLE患者相比，有肾炎的SLE患者血清TIM-3水平较低，差异具有边缘统计学意义（P=0.059）。然而，血清TIM-1和TIM-3水平与SLE疾病活动度均无显著相关性（均>0.05）。综上所述，血清TIM-1和TIM-3水平降低以及TIM-3与肾炎的关联提示它们可能在SLE的发生发展及发病机制中发挥作用。然而，需要进一步研究来证实这些初步结果。
