Capoci Isis Regina Grenier, Cunha Michele Milano da, Bonfim-Mendonça Patricia de Souza, Ghiraldi-Lopes Luciana Dias, Baeza Lilian Cristiane, Kioshima Erika Seki, Svidzinski Terezinha Inez Estivalet
Universidade Estadual de Maringá, Parana, Brazil.
Rev Inst Med Trop Sao Paulo. 2015 Dec;57(6):509-11. doi: 10.1590/S0036-46652015000600008.
Dermatophytosis is a common zoonosis in urban centers. Dogs and cats have played an important role as its disseminators. Environmental decontamination is essential for the prevention of its propagation to humans and animals. However, sanitizers or disinfectants with antifungal activity, currently available, have high toxicity. The present study evaluated the in vitro effects of an extract of citronella (Cymbopogon nardus) on 31 Microsporum canis isolates from animals and home environments. Susceptibility tests were performed based on document M38-A2 (2008) of the Clinical and Laboratory Standards Institute with modifications for natural products. Although susceptibility variation was observed between the fungus tested, the concentrations that inhibited the growth of 50 and 90% of the microorganisms were low (19.5 and 78 µg/mL, respectively). Thus, this citronella extract showed potent fungistatic and fungicide activities against M. canis isolated from animals and home environments. Therefore, it could be an alternative for dermatophytosis prophylaxis in the home environment.
皮肤癣菌病是城市中心常见的人畜共患病。狗和猫作为其传播者发挥了重要作用。环境净化对于预防其传播给人类和动物至关重要。然而,目前可用的具有抗真菌活性的消毒剂或杀菌剂毒性很高。本研究评估了香茅(Cymbopogon nardus)提取物对31株来自动物和家庭环境的犬小孢子菌分离株的体外作用。药敏试验基于临床和实验室标准协会的M38 - A2(2008)文件进行,并针对天然产物进行了修改。尽管在所测试的真菌之间观察到药敏差异,但抑制50%和90%微生物生长的浓度较低(分别为19.5和78 µg/mL)。因此,这种香茅提取物对来自动物和家庭环境的犬小孢子菌显示出强大的抑菌和杀菌活性。因此,它可能是家庭环境中预防皮肤癣菌病的一种替代方法。