[下颌骨放射性骨坏死小型猪模型的建立]
[Establishment of a miniature pig model of mandibular osteoradionecrosis].
作者信息
Song Li, Dianji Fang, Zhanyi Wang, Lulu Zhai, Zhaorong Ning, Yanwei Guo
出版信息
Hua Xi Kou Qiang Yi Xue Za Zhi. 2015 Dec;33(6):570-4. doi: 10.7518/hxkq.2015.06.004.
OBJECTIVE
To establish a miniature pig model of mandibular osteoradionecrosis (ORN).
METHODS
A single dose of irradiation (IR25 Gy, 28 Gy) was delivered via an electronic linear accelerator to the right mandible of 24 miniature pigs by utilizing three dimensional conformal radiotherapy (3D-CRT). The first molar of the mandible was extracted 2 months after radiation. Mandibular ORN was diagnosed through gross observation, X-ray film, CT, and histopathologic examination.
RESULTS
At 3-4 months after radiation, all animals suffered from mandibular ORN after dental extraction. The symptoms of ORN were more severe in the 28 Gy group than in the 25 Gy group.
CONCLUSION
A miniature pig model of mandibular ORN can be established through 25 Gy irradiation + dental extraction.
目的
建立下颌骨放射性骨坏死（ORN）的小型猪模型。
方法
利用三维适形放疗（3D-CRT），通过电子直线加速器对24只小型猪的右侧下颌骨给予单次剂量照射（IR25 Gy、28 Gy）。放疗2个月后拔除下颌第一磨牙。通过大体观察、X线片、CT及组织病理学检查诊断下颌骨ORN。
结果
放疗后3 - 4个月，所有动物拔牙后均发生下颌骨ORN。28 Gy组ORN症状比25 Gy组更严重。
结论
通过25 Gy照射 + 拔牙可建立下颌骨ORN的小型猪模型。
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