Department of Otolaryngology, Head and Neck Surgery, Beth Israel Medical Center, Albert Einstein College of Medicine, New York, NY, USA.
Int J Oral Maxillofac Surg. 2013 Sep;42(9):1121-8. doi: 10.1016/j.ijom.2013.03.022. Epub 2013 May 1.
Osteoradionecrosis (ORN) of the mandible is a severe complication of radiation therapy for head and neck cancer. In this case series, the authors analyzed their treatment and quality of life outcomes over the past 6 years. A retrospective chart review of 42 patients treated surgically for advanced ORN was conducted. A telephone survey was conducted and quality of life (QOL) questionnaires were completed in a subset of patients. 30 patients responded to the telephone survey assessing QOL for speech, swallowing and overall functioning correlated with oral nutrition and performance status. Surgery for ORN can result in an improved QOL. Functional outcomes of oral intake, speech intelligibility, and eating in public correlated with patient rated QOL measures. A lack of improvement in QOL, despite the restoration of an intact mandible, relates to the persistent effects of chemoradiotherapy.
下颌骨放射性骨坏死（ORN）是头颈部癌症放射治疗的严重并发症。在本病例系列中，作者分析了他们在过去 6 年中的治疗和生活质量结果。对 42 例接受手术治疗晚期 ORN 的患者进行了回顾性图表审查。对一部分患者进行了电话调查，并完成了生活质量（QOL）问卷。30 名患者对电话调查做出了回应，评估了与口腔营养和功能状态相关的言语、吞咽和整体功能的 QOL。ORN 的手术治疗可改善生活质量。口腔摄入、言语清晰度和在公共场合进食的功能结果与患者自评 QOL 测量相关。尽管完整的下颌骨得以恢复，但 QOL 仍未改善，这与放化疗的持续影响有关。
