作为失语症治疗反应预测指标的表现变异性
Performance Variability as a Predictor of Response to Aphasia Treatment.
作者信息
Duncan E Susan, Schmah Tanya, Small Steven L
机构信息
University of California, Irvine, CA, USA
Rotman Research Institute, Baycrest, Toronto, ON, Canada University of Ottawa, Ottawa, ON, Canada.
出版信息
Neurorehabil Neural Repair. 2016 Oct;30(9):876-82. doi: 10.1177/1545968316642522. Epub 2016 Apr 6.
BACKGROUND
Performance variability in individuals with aphasia is typically regarded as a nuisance factor complicating assessment and treatment.
OBJECTIVE
We present the alternative hypothesis that intraindividual variability represents a fundamental characteristic of an individual's functioning and an important biomarker for therapeutic selection and prognosis.
METHODS
A total of 19 individuals with chronic aphasia participated in a 6-week trial of imitation-based speech therapy. We assessed improvement both on overall language functioning and repetition ability. Furthermore, we determined which pretreatment variables best predicted improvement on the repetition test.
RESULTS
Significant gains were made on the Western Aphasia Battery-Revised (WAB) Aphasia Quotient, Cortical Quotient, and 2 subtests as well as on a separate repetition test. Using stepwise regression, we found that pretreatment intraindividual variability was the only predictor of improvement in performance on the repetition test, with greater pretreatment variability predicting greater improvement. Furthermore, the degree of reduction in this variability over the course of treatment was positively correlated with the degree of improvement.
CONCLUSIONS
Intraindividual variability may be indicative of potential for improvement on a given task, with more uniform performance suggesting functioning at or near peak potential.
背景
失语症患者的表现变异性通常被视为一个使评估和治疗复杂化的干扰因素。
目的
我们提出另一种假设，即个体内部变异性代表个体功能的一个基本特征，以及治疗选择和预后的一个重要生物标志物。
方法
共有19名慢性失语症患者参加了一项为期6周的基于模仿的言语治疗试验。我们评估了整体语言功能和重复能力的改善情况。此外，我们确定了哪些治疗前变量最能预测重复测试中的改善情况。
结果
在西方失语症成套测验修订版（WAB）失语商数、皮质商数和2个分测验以及单独的重复测试中均取得了显著进步。使用逐步回归分析，我们发现治疗前个体内部变异性是重复测试中表现改善的唯一预测因素，治疗前变异性越大，改善越大。此外，在治疗过程中这种变异性的降低程度与改善程度呈正相关。
结论
个体内部变异性可能表明在给定任务上有改善的潜力，表现越一致表明功能处于或接近峰值潜力。
Zotero 插件