Leite Ingrid Stanize, Castelhano Adelissandra S S, Cysneiros Roberta M
Developmental Disabilities Graduate Program, Laboratory of Neurobiology, Mackenzie Presbyterian University, Rua da Consolação, 930. Prédio 28, CEP 01302-907 São Paulo, SP, Brazil.
Data Brief. 2016 Mar 12;7:686-91. doi: 10.1016/j.dib.2016.03.029. eCollection 2016 Jun.
Status epilepticus (SE), an acute condition characterized by repetitive or ongoing seizures activity, may produce long-term deleterious consequences. Previous data demonstrated that Wistar rats subjected to neonatal SE displayed autistic behavior, characterized by social play impairment, low preference by novelty, deficit in social discrimination; anxiety related behavior and stereotyped behavior with no changes in locomotor activity (doi: http://dx.doi.org/10.1007/s00702-010-0460-1, doi: http://dx.doi.org/10.3389/fnbeh.2013.00036, doi: http://dx.doi.org/10.1007/s00702-014-1291-2[1], [2], [3]). Taking into account the bi-directional relationship between the state of anxiety and social interaction (doi: http://dx.doi.org/10.1007/s10567-009-0062-3[4]), we evaluated the impact of the state of anxiety on social interaction. Male Wistar rats at postnatal day 9 were subjected to pilocarpine-induced neonatal SE (380 mg/kg, ip) and the controls received 0.9% saline (0.1 ml/10 g). The groups received saline or diazepam (1.0 mg/kg) 45 min prior each behavioral testing that started from 60 days of postnatal life. In the open field, rats subjected to neonatal seizure exhibited less central zone activity as compared to animals treated with diazepam, with no changes in the total locomotor activity. In elevated plus maze, rats subjected to neonatal seizure and treated with diazepam exhibited higher locomotor activity and spent more time on the open arms as compared to untreated animals. In approach phase of sociability paradigm, animals subjected to neonatal seizures similarly to controls, regardless the treatment, spent more time with social stimulus as compared to non social stimulus. In social novelty phase of sociability paradigm, animals subjected to neonatal seizures differently of controls, regardless the treatment, spent similar time with familiar and novel stimulus.
癫痫持续状态（SE）是一种以重复性或持续性癫痫发作活动为特征的急性病症，可能会产生长期有害后果。先前的数据表明，经历过新生期癫痫持续状态的Wistar大鼠表现出自闭行为，其特征为社交游戏受损、对新奇事物偏好低、社会辨别能力缺陷；焦虑相关行为和刻板行为，而运动活动无变化（doi: http://dx.doi.org/10.1007/s00702-010-0460-1, doi: http://dx.doi.org/10.3389/fnbeh.2013.00036, doi: http://dx.doi.org/10.1007/s00702-014-1291-2[1], [2], [3]）。考虑到焦虑状态与社交互动之间的双向关系（doi: http://dx.doi.org/10.1007/s10567-009-0062-3[4]），我们评估了焦虑状态对社交互动的影响。出生后第9天的雄性Wistar大鼠接受毛果芸香碱诱导的新生期癫痫持续状态（380mg/kg，腹腔注射），对照组接受0.9%生理盐水（0.1ml/10g）。从出生后60天开始，每组在每次行为测试前45分钟接受生理盐水或地西泮（1.0mg/kg）。在旷场实验中，与接受地西泮治疗的动物相比，经历过新生期癫痫发作的大鼠中央区域活动较少，总运动活动无变化。在高架十字迷宫实验中，与未治疗的动物相比，经历过新生期癫痫发作并接受地西泮治疗的大鼠运动活动更高，在开放臂上花费的时间更多。在社交范式的接近阶段，经历过新生期癫痫发作的动物与对照组类似，无论治疗如何，与社交刺激相比，与非社交刺激相处的时间更多。在社交范式的社交新奇阶段，经历过新生期癫痫发作的动物与对照组不同，无论治疗如何，与熟悉和新奇刺激相处的时间相似。
