Programa de Pós-graduação em Distúrbios do Desenvolvimento, Laboratório de Neurobiologia, Universidade Presbiteriana Mackenzie (UPM), Rua da Consolação, 930. Prédio 38, CEP 01302-907 São Paulo, SP, Brazil.
J Neural Transm (Vienna). 2010 Oct;117(10):1155-60. doi: 10.1007/s00702-010-0460-1. Epub 2010 Aug 15.
Neonatal status epilepticus (SE) disrupts prefrontal cortex and thalamus, brain regions related to social play. Juvenile play was evaluated using the "intruder-resident" paradigm following SE in 9-day-old Wistar pups of both genders. Quite interestingly, we demonstrated for the first time that neonatal SE produces social impairment in male rats, reduces locomotor activity in both genders and enhances self-grooming in female. Additional studies are necessary to clarify if these effects can impair social behavior across the life span.
新生儿癫痫持续状态（SE）会破坏与社交游戏相关的前额叶皮层和丘脑等大脑区域。本研究采用“入侵者-居民”范式，在 9 日龄雄性和雌性 Wistar 幼鼠中建立 SE 模型，评估其幼年社交行为。有趣的是，我们首次发现 SE 会导致雄性幼鼠出现社交障碍，降低两性的运动活动，并增强雌性幼鼠的自我修饰行为。需要进一步研究以明确这些影响是否会损害整个生命周期的社会行为。
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