Programa de Pós-graduação em Distúrbios do Desenvolvimento, Laboratório de Neurobiologia, Universidade Presbiteriana Mackenzie, Rua da Consolação, 930. Prédio 38, CEP 01302-907 São Paulo, Brazil.
J Neural Transm (Vienna). 2012 Jun;119(6):639-44. doi: 10.1007/s00702-011-0751-1. Epub 2012 Feb 23.
Human and animal models have demonstrated that maternal seizures in utero could be deleterious to the development of the offspring. This study focused on the social behavior of offspring exposed to seizures in utero. A pilocarpine model of temporal lobe epilepsy was induced in female Wistar rats that were mated after the first spontaneous seizure. Early after birth, pups from an epileptic mother were reared by a control mother. To evaluate the influence of the adoption process, two other groups were added: rat pups from control mothers cross-fostered with other control mothers, and rat pups reared by their birth mother. Animals exposed to seizures in utero showed impaired social behavior with no signs of anxiety-like behavior. This study demonstrated that epileptic seizures during pregnancy could be harmful to brain development and may increase the risk of developing neurodevelopmental disorders. The mechanisms underlying the abnormalities of social behavior are not well understood, and further studies in this field are warranted.
人类和动物模型已经证明，子宫内的母体癫痫发作可能对后代的发育有害。本研究专注于子宫内癫痫发作暴露的后代的社会行为。在第一次自发性癫痫发作后交配的雌性 Wistar 大鼠中诱导颞叶癫痫的匹鲁卡品模型。在出生后早期，来自癫痫母亲的幼崽由对照母亲抚养。为了评估收养过程的影响，又添加了另外两组：来自对照母亲的幼崽与其他对照母亲交叉寄养，以及由其生母抚养的幼崽。子宫内暴露于癫痫发作的动物表现出社交行为受损，没有焦虑样行为的迹象。本研究表明，妊娠期间的癫痫发作可能对大脑发育有害，并可能增加发育神经障碍的风险。社交行为异常的潜在机制尚不清楚，需要在该领域进行进一步研究。
