Pacífico Ana Miriã, Batista Samuel P, Ribeiro Fernanda T, Santos Pedro B Dos, Silveira Gabriel Bruno, Pedrico do Nascimento Bruna Pascarelli, Junior Eduardo Dias, Barbosa Geraldo Henrique L, Ribeiro Miriam Oliveira, da Silva Sergio Gomes, Cysneiros Roberta M
Developmental Disabilities Graduate Program. Mackenzie Presbyterian University, São Paulo, Brazil. Rua da Consolação, 930. Prédio 28, CEP 01302-907 São Paulo, SP, Brazil.
Hospital do Câncer de Muriaé - Fundação Cristiano Varella, Muriaé, Brazil.
Data Brief. 2020 Jun 7;31:105819. doi: 10.1016/j.dib.2020.105819. eCollection 2020 Aug.
Early-life produces deficit in social interaction and vocalization, enhances anxiety, no cognitive impairment and alters functional connectivity within the hippocampus (CA3-CA1) and between the hippocampus and prefrontal cortex [1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], but the underlying mechanisms remain unknown. This data article contains behavioral and molecular data of the adult male Wistar rats subjected to early life pilocarpine-induced seizures. Animal's behaviors were assessed to social memory and social motivation, working and reference memories and cognitive flexibility. The brain tissues (hypothalamus, hippocampus, amygdala, and striatum) were probed to gene and protein expression of molecules related to social behavior, reward system and synaptic function.
早期生活经历会导致社交互动和发声方面的缺陷，加剧焦虑情绪，不会造成认知障碍，并改变海马体内部（CA3-CA1）以及海马体与前额叶皮质之间的功能连接[1,2,3,4,5,6,7,8,9,10,11,12]，但其潜在机制仍不清楚。本数据文章包含成年雄性Wistar大鼠在早期因毛果芸香碱诱发癫痫发作后的行为和分子数据。评估了动物在社交记忆、社交动机、工作记忆、参考记忆和认知灵活性方面的行为。对脑组织（下丘脑、海马体、杏仁核和纹状体）进行检测，以了解与社交行为、奖励系统和突触功能相关分子的基因和蛋白质表达情况。
