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Neuroprotective and neurorestorative potential of xenon.

作者信息

Lavaur J, Lemaire M, Pype J, Le Nogue D, Hirsch E C, Michel P P

机构信息

Institut National de la Santé et de la Recherche Médicale, U 1127, CNRS, Unité Mixte de Recherche (UMR) 7225, Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Paris, France.

Air Liquide Healthcare, Medical R&D Paris, Saclay Research Center, Jouy-en Josas, France.

出版信息

Cell Death Dis. 2016 Apr 7;7(4):e2182. doi: 10.1038/cddis.2016.86.

DOI:10.1038/cddis.2016.86
PMID:27054337
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4855665/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f83e/4855665/62a19564e80d/cddis201686f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f83e/4855665/62a19564e80d/cddis201686f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f83e/4855665/62a19564e80d/cddis201686f1.jpg

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2
The noble gas xenon provides protection and trophic stimulation to midbrain dopamine neurons.惰性气体氙对中脑多巴胺神经元具有保护和营养刺激作用。
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Neuroprotection of dopamine neurons by xenon against low-level excitotoxic insults is not reproduced by other noble gases.氙气对多巴胺神经元的神经保护作用可抵抗低水平兴奋性毒性损伤，但其他稀有气体则不能。
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Neuroprotection against traumatic brain injury by xenon, but not argon, is mediated by inhibition at the N-methyl-D-aspartate receptor glycine site.氙气而非氩气通过抑制 N-甲基-D-天冬氨酸受体甘氨酸位点实现对创伤性脑损伤的神经保护作用。
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Attenuated iron stress and oxidative stress may participate in anti-seizure and neuroprotective roles of xenon in pentylenetetrazole-induced epileptogenesis.减轻的铁应激和氧化应激可能参与了氙气在戊四氮诱导癫痫发生过程中的抗癫痫和神经保护作用。
Front Cell Neurosci. 2022 Nov 17;16:1007458. doi: 10.3389/fncel.2022.1007458. eCollection 2022.
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本文引用的文献

1
Xenon-mediated neuroprotection in response to sustained, low-level excitotoxic stress.氙气介导的针对持续性低水平兴奋性毒性应激的神经保护作用。
Cell Death Discov. 2016 May 16;2:16018. doi: 10.1038/cddiscovery.2016.18. eCollection 2016.
2
The diverse biological properties of the chemically inert noble gases.稀有气体的化学惰性与其多样的生物属性。
Pharmacol Ther. 2016 Apr;160:44-64. doi: 10.1016/j.pharmthera.2016.02.002. Epub 2016 Feb 16.
3
Chronic Glutamate Toxicity in Neurodegenerative Diseases-What is the Evidence?神经退行性疾病中的慢性谷氨酸毒性——证据是什么？
Xenon Exerts Neuroprotective Effects on Kainic Acid-Induced Acute Generalized Seizures in Rats Increased Autophagy.
氙对大鼠海人酸诱导的急性全身性癫痫发作具有神经保护作用 增加自噬。
Front Cell Neurosci. 2020 Oct 6;14:582872. doi: 10.3389/fncel.2020.582872. eCollection 2020.
4
Neuroprotection of dopamine neurons by xenon against low-level excitotoxic insults is not reproduced by other noble gases.氙气对多巴胺神经元的神经保护作用可抵抗低水平兴奋性毒性损伤，但其他稀有气体则不能。
J Neural Transm (Vienna). 2020 Jan;127(1):27-34. doi: 10.1007/s00702-019-02112-x. Epub 2019 Dec 5.
5
Mode-Dependent Effect of Xenon Inhalation on Kainic Acid-Induced Status Epilepticus in Rats.氙气吸入对大鼠海人酸诱导的癫痫持续状态的模式依赖性影响。
Front Cell Neurosci. 2019 Aug 14;13:375. doi: 10.3389/fncel.2019.00375. eCollection 2019.
6
Mapping Hydrophobic Tunnels and Cavities in Neuroglobin with Noble Gas under Pressure.在压力下用稀有气体绘制神经球蛋白中的疏水通道和腔
Biophys J. 2017 Nov 21;113(10):2199-2206. doi: 10.1016/j.bpj.2017.10.014. Epub 2017 Nov 3.
7
Protection of xenon against postoperative oxygen impairment in adults undergoing Stanford Type-A acute aortic dissection surgery: Study protocol for a prospective, randomized controlled clinical trial.氙气对 Stanford A 型急性主动脉夹层手术成年患者术后氧损伤的保护作用：一项前瞻性随机对照临床试验的研究方案
Medicine (Baltimore). 2017 Aug;96(34):e7857. doi: 10.1097/MD.0000000000007857.
8
The noble gas xenon provides protection and trophic stimulation to midbrain dopamine neurons.惰性气体氙对中脑多巴胺神经元具有保护和营养刺激作用。
J Neurochem. 2017 Jul;142(1):14-28. doi: 10.1111/jnc.14041. Epub 2017 May 16.
9
Effects of pulmonary static inflation with 50% xenon on oxygen impairment during cardiopulmonary bypass for stanford type A acute aortic dissection: A pilot study.50%氙气肺静态充气对斯坦福A型急性主动脉夹层体外循环期间氧损伤的影响：一项初步研究。
Medicine (Baltimore). 2017 Mar;96(10):e6253. doi: 10.1097/MD.0000000000006253.
Front Neurosci. 2015 Dec 16;9:469. doi: 10.3389/fnins.2015.00469. eCollection 2015.
4
Cell number changes in Alzheimer's disease relate to dementia, not to plaques and tangles.阿尔茨海默病中的细胞数量变化与痴呆有关，而与斑块和缠结无关。
Brain. 2013 Dec;136(Pt 12):3738-52. doi: 10.1093/brain/awt273. Epub 2013 Oct 17.
5
Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss.Aβ 诱导星形胶质细胞谷氨酸释放、突触外 NMDA 受体激活和突触丢失。
Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2518-27. doi: 10.1073/pnas.1306832110. Epub 2013 Jun 17.
6
Dopamine protects neurons against glutamate-induced excitotoxicity.多巴胺可保护神经元免受谷氨酸诱导的兴奋性毒性。
Cell Death Dis. 2013 Jan 10;4(1):e455. doi: 10.1038/cddis.2012.194.
7
Xenon and sevoflurane provide analgesia during labor and fetal brain protection in a perinatal rat model of hypoxia-ischemia.氙气和七氟醚在围产期缺氧缺血大鼠模型中提供分娩镇痛和胎儿脑保护。
PLoS One. 2012;7(5):e37020. doi: 10.1371/journal.pone.0037020. Epub 2012 May 17.
8
Mechanistic insights into xenon inhibition of NMDA receptors from MD simulations.氙气对 NMDA 受体抑制作用的分子动力学模拟研究。
J Phys Chem B. 2010 Jul 15;114(27):9010-6. doi: 10.1021/jp101687j.
9
Competitive inhibition at the glycine site of the N-methyl-D-aspartate receptor mediates xenon neuroprotection against hypoxia-ischemia.竞争抑制 N-甲基-D-天冬氨酸受体甘氨酸结合部位介导氙气对缺氧缺血的神经保护作用。
Anesthesiology. 2010 Mar;112(3):614-22. doi: 10.1097/ALN.0b013e3181cea398.
10
Regulation of cholinergic phenotype in developing neurons.发育中神经元胆碱能表型的调控。
J Neurophysiol. 2008 May;99(5):2443-55. doi: 10.1152/jn.00762.2007. Epub 2008 Mar 5.