Dalal N S, Suryan M M, Vallyathan V, Green F H, Jafari B, Wheeler R
Ann Occup Hyg. 1989;33(1):79-84. doi: 10.1093/annhyg/33.1.79.
Freshly ground and aged anthracite and bituminous coal samples were investigated by electron spin resonance (ESR) spectroscopy to detect the presence, concentration and reactivity of free radicals. Freshly ground anthracite coal produced greater concentration of free radicals than the bituminous coal, and the radical reactivity was also greater for the anthracite. The reactivity of the newly produced free radicals in the anthracite dust correlated with the dust's toxicity. Furthermore, similar coal-based free radicals were detected in the lung tissue of autopsied coal miners, suggestive of persistent reactivity by the embedded coal dust leading to the progressive disease process. Results of the studies on the severity of coal workers' pneumoconiosis (CWP) and free radical concentration in lung tissue support this hypothesis.
通过电子自旋共振（ESR）光谱对新鲜研磨和老化的无烟煤和烟煤样品进行了研究，以检测自由基的存在、浓度和反应性。新鲜研磨的无烟煤产生的自由基浓度高于烟煤，且无烟煤的自由基反应性也更高。无烟煤粉尘中新产生的自由基的反应性与粉尘的毒性相关。此外，在尸检的煤矿工人肺组织中检测到了类似的煤基自由基，这表明嵌入的煤尘具有持续的反应性，导致疾病的进展过程。关于煤工尘肺（CWP）严重程度和肺组织中自由基浓度的研究结果支持了这一假设。
