Adelman C, Linder N, Levi H
Speech and Hearing Center, Hadassah University Hospital, Jerusalem.
Ann Otol Rhinol Laryngol. 1989 Apr;98(4 Pt 1):283-6. doi: 10.1177/000348948909800409.
Thirty-two infants (18 full-term and 14 premature) who had been treated with gentamicin as neonates were examined to ascertain whether this drug induced hearing loss, even of low severity. Objective thresholds to clicks were obtained using auditory nerve and brain stem evoked responses. In addition, behavioral audiometry was performed. Serum concentrations before and after gentamicin treatment were at therapeutic levels. All infants were examined at least 1 1/4 months after cessation of therapy. Normal thresholds were obtained in all ears, with the exception of two with demonstrable middle ear effusion. It appears that gentamicin in therapeutic doses and serum concentrations, in the absence of renal insufficiency, does not cause hearing loss in neonates.
对32名曾在新生儿期接受庆大霉素治疗的婴儿（18名足月儿和14名早产儿）进行了检查，以确定这种药物是否会导致听力损失，即使是轻度的听力损失。使用听神经和脑干诱发反应获得了对咔嗒声的客观阈值。此外，还进行了行为测听。庆大霉素治疗前后的血清浓度均处于治疗水平。所有婴儿在停止治疗后至少1又1/4个月接受了检查。除两名有明显中耳积液的婴儿外，所有耳朵的阈值均正常。在没有肾功能不全的情况下，治疗剂量和血清浓度的庆大霉素似乎不会导致新生儿听力损失。
