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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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Radioimmunoassay of creatine kinase isoenzymes.
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10
Effect of dietary selenium on glutathione peroxidase in the chick.日粮硒对雏鸡谷胱甘肽过氧化物酶的影响。
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谷胱甘肽过氧化物酶蛋白。在硒缺乏状态下缺失及其与酶活性的相关性。

Glutathione peroxidase protein. Absence in selenium deficiency states and correlation with enzymatic activity.

作者信息

Takahashi K, Newburger P E, Cohen H J

出版信息

J Clin Invest. 1986 Apr;77(4):1402-4. doi: 10.1172/JCI112449.

DOI:10.1172/JCI112449
PMID:3457020
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC424509/
Abstract

Glutathione peroxidase (GSHPx) activity is an indicator of selenium status in selenium-deficient individuals. Utilizing polyclonal monospecific antibodies to purified erythrocyte GSHPx, we were able to determine the relationship between enzymatic activity and protein content. In erythrocytes from a selenium-deficient individual who was treated with selenium, and in HL-60 cells grown in the absence of selenium and then returned to selenium-containing medium, there was a direct relationship between enzymatic activity and protein content. Thus, selenium deficiency results not only in a decrease of GSHPx activity, but also in a decrease of GSHPx protein.

摘要

谷胱甘肽过氧化物酶（GSHPx）活性是缺硒个体硒状态的一个指标。利用针对纯化红细胞GSHPx的多克隆单特异性抗体，我们能够确定酶活性与蛋白质含量之间的关系。在接受硒治疗的缺硒个体的红细胞中，以及在无硒条件下培养然后再回到含硒培养基中生长的HL-60细胞中，酶活性与蛋白质含量之间存在直接关系。因此，硒缺乏不仅导致GSHPx活性降低，还导致GSHPx蛋白减少。