Ortega Francisco J, Agüera Zaida, Sabater Mònica, Moreno-Navarrete José M, Alonso-Ledesma Isabel, Xifra Gemma, Botas Patricia, Delgado Elías, Jimenez-Murcia Susana, Fernández-García José C, Tinahones Francisco J, Baños Rosa M, Botella Cristina, de la Torre Rafael, Frühbeck Gema, Rodrigüez Amaia, Estivill Xavier, Casanueva Felipe, Ricart Wifredo, Fernández-Aranda Fernando, Fernández-Real José M
CIBER de la Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), and Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Service of Diabetes, Endocrinology and Nutrition (UDEN), and Institut d'Investigació Biomédica de Girona (IdIBGi), Girona, Spain.
Mol Nutr Food Res. 2016 Jul;60(7):1673-83. doi: 10.1002/mnfr.201500804. Epub 2016 May 27.
Changes in genetic variations affecting the taste receptor, type 2, member 38 (TAS2R38) may identify the interacting mechanism leading to obesity and potential associations with proteins partaking in innate immunity, such as surfactant protein D (SPD) and mannan-binding lectin (MBL).
We evaluated haplotypes of the bitter-taste receptor TAS2R38 in an identification sample of 210 women in different weight conditions, including anorexia nervosa and obesity. The association with SPD and MBL was tested in an independent sample picturing general population (n = 534). The relationship with obesity was validated in an extended final sample of 1319 participants. In the sample comprised of women in extreme weight conditions, increased obesity was identified in AVI/AVI subjects (OR = 2.5 [1.06-6.11], p = 0.035). In the sample picturing general population, increased SPD and MBL concentrations were found in nonsmoking AVI carriers. In this cohort, smoking and obesity blunted associations between TAS2R38 haplotypes and SPD and MBL. In the extended sample, the association of AVI/AVI haplotypes with increased obesity was also identified (OR = 1.4 [0.99/1.85], p = 0.049), being more robust in subjects aged <40 years (OR = 1.9 [1.06/3.42], p = 0.031).
Current data reinforce the impact of TAS2R38 gene on phenotypic and clinical outputs affecting obesity, showing significant associations with extreme weight conditions (i.e., obesity and anorexia nervosa), and changes in both olfactory capacity and immune traits.
影响味觉受体2型成员38（TAS2R38）的基因变异变化可能揭示导致肥胖的相互作用机制，以及与参与先天免疫的蛋白质（如表面活性蛋白D（SPD）和甘露糖结合凝集素（MBL））的潜在关联。
我们在210名处于不同体重状况（包括神经性厌食症和肥胖症）的女性识别样本中评估了苦味受体TAS2R38的单倍型。在描绘普通人群的独立样本（n = 534）中测试了其与SPD和MBL的关联。在1319名参与者的扩展最终样本中验证了其与肥胖的关系。在由极端体重状况的女性组成的样本中，AVI/AVI受试者的肥胖发生率增加（OR = 2.5 [1.06 - 6.11]，p = 0.035）。在描绘普通人群的样本中，发现非吸烟的AVI携带者中SPD和MBL浓度增加。在该队列中，吸烟和肥胖减弱了TAS2R38单倍型与SPD和MBL之间的关联。在扩展样本中，也确定了AVI/AVI单倍型与肥胖增加的关联（OR = 1.4 [0.99 / 1.85]，p = 0.049），在年龄<40岁的受试者中更为显著（OR = 1.9 [1.06 / 3.42]，p = 0.031）。
当前数据强化了TAS2R38基因对影响肥胖的表型和临床结果的影响，显示出与极端体重状况（即肥胖症和神经性厌食症）以及嗅觉能力和免疫特征变化的显著关联。
