Ud-Din Sara, Bayat Ardeshir
Plastic and Reconstructive Surgery Research, Institute of Inflammation and Repair, University of Manchester, Manchester, UK.
University Hospital of South Manchester NHS Foundation Trust, Faculty of Medical and Human Sciences, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
Exp Dermatol. 2016 Aug;25(8):579-85. doi: 10.1111/exd.13027. Epub 2016 Jun 15.
Objective evaluation of cutaneous wounds through the use of non-invasive devices is important for diagnosis, monitoring treatment response and can lead to the development of improved theranostic strategies. The need for objective monitoring of wound healing and scar formation is evident as this enables accurate diagnosis, evaluation and prognosis for clinicians and allows for the standardisation and validation of methodology for researchers. Therefore, this review provides an overview of the current application of non-invasive objective technologies for the assessment of wound healing through the different phases of repair. We propose that cutaneous healing parameters can be split into three core domains: anatomical, mechanical and physiological. These categories can be further subdivided with respect to specific phases of healing. There is no single instrument, which can measure all the parameters of healing simultaneously; thus, it is important to choose the correct device for the particular healing characteristics being monitored. However, multiprobe systems, which include a number of devices connected to one main unit, are useful as they enable multiple measurements of different parameters. Many of the devices have not been validated against histological examination. Additionally, some of the instruments have not been evaluated in all wound or scar types and may not be useful throughout all phases of cutaneous wound healing. In conclusion, non-invasive objective devices are useful in the assessment of cutaneous wound healing, as these tools can link the treatment and diagnosis by evaluating response to treatment and thus could aid as a marker for healing and scar maturation.
通过使用非侵入性设备对皮肤伤口进行客观评估对于诊断、监测治疗反应非常重要，并且可能会促成改进的治疗诊断策略的发展。对伤口愈合和瘢痕形成进行客观监测的需求是显而易见的，因为这能为临床医生提供准确的诊断、评估和预后信息，也能让研究人员实现方法的标准化和验证。因此，本综述概述了目前非侵入性客观技术在评估伤口愈合不同修复阶段中的应用。我们提出，皮肤愈合参数可分为三个核心领域：解剖学、力学和生理学。这些类别可根据愈合的特定阶段进一步细分。没有一种仪器能够同时测量所有愈合参数；因此，根据所监测的特定愈合特征选择正确的设备很重要。然而，多探头系统（包括连接到一个主机的多个设备）很有用，因为它们能够对不同参数进行多次测量。许多设备尚未经过组织学检查验证。此外，一些仪器尚未在所有伤口或瘢痕类型中进行评估，可能在皮肤伤口愈合的所有阶段都不适用。总之，非侵入性客观设备在评估皮肤伤口愈合方面很有用，因为这些工具可以通过评估治疗反应将治疗与诊断联系起来，从而有助于作为愈合和瘢痕成熟的标志物。
