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瘢痕疙瘩和增生性瘢痕的整骨疗法

Osteopathic Approach for Keloids and Hypertrophic Scars.

作者信息

Bordoni Bruno, Escher Allan R, Girgenti Gregory T, Tobbi Filippo, Bonanzinga Roberto

机构信息

Physical Medicine and Rehabilitation, Foundation Don Carlo Gnocchi, Milan, ITA.

Anesthesiology/Pain Medicine, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA.

出版信息

Cureus. 2023 Sep 7;15(9):e44815. doi: 10.7759/cureus.44815. eCollection 2023 Sep.

DOI:10.7759/cureus.44815
PMID:37692181
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10483258/
Abstract

The skin is a complex organ, a system that influences and is influenced by the body system, with different skin layers always mechano-biologically active. In the presence of a lesion that damages the dermis, the skin undergoes sensory, morphological, and functional alterations. The subsequent adaptation is the formation of scar tissue, following distinct and overlapping biological phases. For reasons not yet fully elucidated, some healing processes lead to pathological scars, from which symptoms such as pain, itching, and functional limitations are derived. Currently, there is no gold standard treatment that fully meets the needs of different scars and can eliminate any symptoms that the patient suffers. One such treatment is manual medicine, which involves direct manual approaches to the site of injury. Reviewing the phases that allow the skin to be remodeled following an injury, this article reflects on the usefulness of resorting to these procedures, highlighting erroneous concepts on which the manual approach is based, compared to what the current literature highlights the cicatricial processes. Considering pathological scar adaptations, it would be better to follow a gentle manual approach.

摘要

皮肤是一个复杂的器官,是一个受身体系统影响并反过来影响身体系统的系统,不同的皮肤层始终具有机械生物学活性。在存在损害真皮的病变时,皮肤会经历感觉、形态和功能改变。随后的适应性变化是形成瘢痕组织,这遵循不同且相互重叠的生物学阶段。由于尚未完全阐明的原因,一些愈合过程会导致病理性瘢痕,从中产生疼痛、瘙痒和功能受限等症状。目前,没有一种能完全满足不同瘢痕需求并消除患者所遭受的任何症状的金标准治疗方法。手动医学就是这样一种治疗方法,它涉及对损伤部位进行直接的手动操作。回顾损伤后使皮肤重塑的各个阶段,本文思考采用这些操作程序的实用性,突出了与当前文献所强调的瘢痕形成过程相比,手动操作方法所基于的错误观念。考虑到病理性瘢痕的适应性变化,最好采用温和的手动操作方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d191/10483258/cefa22671f06/cureus-0015-00000044815-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d191/10483258/413af2d274f8/cureus-0015-00000044815-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d191/10483258/cefa22671f06/cureus-0015-00000044815-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d191/10483258/413af2d274f8/cureus-0015-00000044815-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d191/10483258/cefa22671f06/cureus-0015-00000044815-i02.jpg

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本文引用的文献

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New insights into balancing wound healing and scarless skin repair.关于平衡伤口愈合与无瘢痕皮肤修复的新见解。
J Tissue Eng. 2023 Jul 27;14:20417314231185848. doi: 10.1177/20417314231185848. eCollection 2023 Jan-Dec.
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Congress Report on the Second World Congress of Global Scar Society with Scar Academy and Japan Scar Workshop.关于全球瘢痕协会第二届世界大会暨瘢痕研究院与日本瘢痕研讨会的国会报告。
Plast Reconstr Surg Glob Open. 2023 Apr 14;11(4):e4921. doi: 10.1097/GOX.0000000000004921. eCollection 2023 Apr.
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Effectiveness of various methods of manual scar therapy.
各种手动瘢痕治疗方法的效果。
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Extracellular matrix stiffness-The central cue for skin fibrosis.细胞外基质硬度——皮肤纤维化的核心线索。
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Scar/WAVE has Rac GTPase-independent functions during cell wound repair.Scar/WAVE 在细胞创伤修复过程中具有 Rac GTPase 非依赖性功能。
Sci Rep. 2023 Mar 23;13(1):4763. doi: 10.1038/s41598-023-31973-2.
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Molecular Mechanisms of Neurogenic Inflammation of the Skin.皮肤神经源性炎症的分子机制。
Int J Mol Sci. 2023 Mar 5;24(5):5001. doi: 10.3390/ijms24055001.
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An Updated Review of Hypertrophic Scarring.增生性瘢痕的最新综述。
Cells. 2023 Feb 21;12(5):678. doi: 10.3390/cells12050678.
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Mapping the 3D remodeling of the extracellular matrix in human hypertrophic scar by multi-parametric multiphoton imaging using endogenous contrast.利用内源性对比剂通过多参数多光子成像绘制人类增生性瘢痕细胞外基质的三维重塑图。
Heliyon. 2023 Feb 13;9(2):e13653. doi: 10.1016/j.heliyon.2023.e13653. eCollection 2023 Feb.
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