Carpenter A M, Muchow D, Goycoolea M V
Department of Anatomy, University of Minnesota School of Medicine, Minneapolis.
Arch Otolaryngol Head Neck Surg. 1989 May;115(5):585-90. doi: 10.1001/archotol.1989.01860290043012.
An ultrastructural study of 14 round window membranes of seven human ears disclosed three basic layers: an outer epithelium lining the middle ear, a middle core of connective tissue, and an inner epithelium bordering the inner ear. Morphological evidence suggests that these layers participate in absorption and secretion of substances to and from the inner ear. A comparison of morphological features of round window membranes suggests that the average thickness of 70 microns does not change with advancing age. However, in the elderly, the connective tissue has a looser arrangement; there is an increase in ground substance; and elastic fibers thicken. Fibroblast nuclei become larger, rounder, and less uniform and have extensions. The ultrastructure of the "false round window membranes," with epithelial cells of the same type bounding both sides, suggests that these membranes consist of juxtaposed epithelial folds of the overlying promontory.
对七个人类耳朵的14个圆窗膜进行的超微结构研究揭示了三个基本层：中耳内衬的外层上皮、结缔组织的中间核心以及与内耳相邻的内层上皮。形态学证据表明，这些层参与内耳物质的吸收和分泌。圆窗膜形态特征的比较表明，平均70微米的厚度不会随着年龄的增长而改变。然而，在老年人中，结缔组织排列更松散；基质增加；弹性纤维变厚。成纤维细胞核变得更大、更圆且更不均匀，并具有延伸部分。“假圆窗膜”的超微结构，两侧均由相同类型的上皮细胞界定，表明这些膜由覆盖在前庭上的并列上皮褶皱组成。
