Castanheira Mariana, Messer Shawn A, Rhomberg Paul R, Pfaller Michael A
JMI Laboratories, North Liberty, IA, USA.
JMI Laboratories, North Liberty, IA, USA.
Diagn Microbiol Infect Dis. 2016 Jun;85(2):200-4. doi: 10.1016/j.diagmicrobio.2016.02.009. Epub 2016 Feb 9.
Among 1846 fungal clinical isolates from 31 countries, echinocandin resistance in Candida spp. ranged from 0.0% to 2.8% (highest for anidulafungin versus Candida glabrata), and fluconazole resistance was noted among 11.9% and 11.6% of the C. glabrata and Candida tropicalis, respectively. Two isolates of Aspergillus fumigatus displayed elevated MICs for itraconazole and carried cyp51a mutations encoding TR34 L98H. All Cryptococcus neoformans had azole MIC values below epidemiological cutoff values. The increasing resistance among certain species and more frequent reports of breakthrough infections in patients undergoing antifungal therapy highlights the importance of antifungal surveillance to guide therapy for patients with invasive fungal infections.
在来自31个国家的1846株真菌临床分离株中，念珠菌属对棘白菌素的耐药率为0.0%至2.8%（对光滑念珠菌而言，阿尼芬净的耐药率最高），光滑念珠菌和热带念珠菌对氟康唑的耐药率分别为11.9%和11.6%。两株烟曲霉分离株对伊曲康唑的最低抑菌浓度（MIC）升高，并携带编码TR34 L98H的cyp51a突变。所有新生隐球菌的唑类MIC值均低于流行病学截断值。某些菌种耐药性的增加以及接受抗真菌治疗的患者中突破性感染报告的增多，凸显了抗真菌监测对于指导侵袭性真菌感染患者治疗的重要性。
