Key Laboratory of Mesoscopic Chemistry of MOE Center for Multimolecular Organic Chemistry School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, P. R. China.
Chem Rec. 2016 Jun;16(3):1216-27. doi: 10.1002/tcr.201500265. Epub 2016 Apr 7.
Supramolecular drug delivery systems (SDDSs), including various kinds of nanostructures that are assembled by reversible noncovalent interactions, have attracted considerable attention as ideal drug carriers owing to their fascinating ability to undergo dynamic switching of structure, morphology, and function in response to various external stimuli, which provides a flexible and robust platform for designing and developing functional and smart supramolecular nano-drug carriers. Pillar[n]arenes represent a new generation of macrocyclic hosts, which have unique structures and excellent properties in host-guest chemistry. This account describes recent progress in our group to develop pillararene-based stimuli-responsive supramolecular nanostructures constructed by reversible host-guest interactions for controllable anticancer drug delivery. The potential applications of these supramolecular drug carriers in cancer treatment and the fundamental questions facing SDDSs are also discussed.
超分子药物递送系统（SDDSs），包括通过可逆非共价相互作用组装的各种纳米结构，由于其在各种外部刺激下具有结构、形态和功能的动态切换的迷人能力，作为理想的药物载体引起了相当大的关注，为设计和开发功能和智能超分子纳米药物载体提供了一个灵活而强大的平台。柱芳烃代表了新一代大环主体，在主客体化学中具有独特的结构和优异的性质。本说明描述了我们小组最近在开发基于柱芳烃的刺激响应超分子纳米结构方面的进展，这些纳米结构是通过可逆主客体相互作用构建的，用于可控抗癌药物递送。还讨论了这些超分子药物载体在癌症治疗中的潜在应用以及 SDDSs 面临的基本问题。
