Weintraub David, Elias W Jeffrey
Department of Neurosurgery, University of Virginia, Charlottesville, Virginia, USA.
Mov Disord. 2017 Jan;32(1):20-27. doi: 10.1002/mds.26599. Epub 2016 Apr 8.
To review the emerging role of transcranial MR-guided focused ultrasound as a treatment and research modality for functional neurological disorders, we summarize recent clinical and preclinical studies. Clinical trials have investigated the safety and efficacy of thermal lesions created by transcranial, high-intensity focused ultrasound. Preclinical work has additionally investigated the ability to disrupt the blood-brain barrier and to produce reversible neuromodulation with focused ultrasound utilizing lower intensities. We discuss ongoing trials and future avenues of investigation. © 2016 International Parkinson and Movement Disorder Society.
为了回顾经颅磁共振引导聚焦超声作为一种治疗和研究功能性神经障碍的新兴手段的作用，我们总结了近期的临床和临床前研究。临床试验已经研究了经颅高强度聚焦超声产生的热损伤的安全性和有效性。临床前研究还额外探究了利用较低强度的聚焦超声破坏血脑屏障以及产生可逆性神经调节的能力。我们讨论了正在进行的试验以及未来的研究方向。© 2016国际帕金森病和运动障碍协会
