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[大黄素抗肿瘤作用的研究进展]

[Research progress in anti-tumor effect of emodin].

作者信息

Lin Wan-fu, Wang Chen, Ling Chang-quan

出版信息

Zhongguo Zhong Yao Za Zhi. 2015 Oct;40(20):3937-40.

PMID:27062805
Abstract

Emodin is one of the main active ingredient of Rheum palmatum, and has anti-inflammatory, anti-bacterial, anti-viral and other effects. In recent years, it arouse concern since it has a significant anti-tumor effect with low toxicity. In this paper we mainly report the anti-cancer effects of emodin according to the studies of the past five years, including four parts such as inhibit tumor growth, inhibit migration and invasion, enhance the efficacy of combination therapy, increase chemosensitivity and attenuated side effects. We hope that our work may provide a reference for further study.

摘要

大黄素是掌叶大黄的主要活性成分之一,具有抗炎、抗菌、抗病毒等作用。近年来,因其具有显著的抗肿瘤作用且毒性低而受到关注。本文主要根据过去五年的研究报道大黄素的抗癌作用,包括抑制肿瘤生长、抑制迁移和侵袭、增强联合治疗疗效、增加化疗敏感性和减轻副作用等四个方面。希望我们的工作可为进一步研究提供参考。

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1
[Research progress in anti-tumor effect of emodin].[大黄素抗肿瘤作用的研究进展]
Zhongguo Zhong Yao Za Zhi. 2015 Oct;40(20):3937-40.
2
Blockade of Her2/neu binding to Hsp90 by emodin azide methyl anthraquinone derivative induces proteasomal degradation of Her2/neu.大黄素氮芥甲基蒽醌衍生物通过阻断 Her2/neu 与 Hsp90 的结合诱导 Her2/neu 的蛋白酶体降解。
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Potential antineoplastic effects of Aloe-emodin: a comprehensive review.大黄素的潜在抗肿瘤作用:全面综述。
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[Progress of research on molecular mechanisms in antitumor effect of emodin].[大黄素抗肿瘤作用分子机制的研究进展]
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 Jan;29(1):85-8.
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Anti-proliferative effects of estrogen receptor-modulating compounds isolated from Rheum palmatum.从掌叶大黄中分离出的雌激素受体调节化合物的抗增殖作用。
Arch Pharm Res. 2008 Jun;31(6):722-6. doi: 10.1007/s12272-001-1218-1. Epub 2008 Jun 19.
6
Anthraquinone emodin inhibits human cancer cell invasiveness by antagonizing P2X7 receptors.蒽醌大黄素通过拮抗 P2X7 受体抑制人癌细胞侵袭。
Carcinogenesis. 2013 Jul;34(7):1487-96. doi: 10.1093/carcin/bgt099. Epub 2013 Mar 23.
7
The Health Benefits of Emodin, a Natural Anthraquinone Derived from Rhubarb-A Summary Update.大黄素的健康益处,一种源自大黄的天然蒽醌-综述更新。
Int J Mol Sci. 2021 Sep 1;22(17):9522. doi: 10.3390/ijms22179522.
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Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer.大黄素通过靶向阻断多种信号转导通路治疗炎症性疾病和癌症。
Cancer Lett. 2013 Dec 1;341(2):139-49. doi: 10.1016/j.canlet.2013.08.023. Epub 2013 Aug 17.
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Emodin loaded solid lipid nanoparticles: preparation, characterization and antitumor activity studies.载有大黄素的固体脂质纳米粒的制备、表征及抗肿瘤活性研究。
Int J Pharm. 2012 Jul 1;430(1-2):238-46. doi: 10.1016/j.ijpharm.2012.03.027. Epub 2012 Mar 23.
10
The combined effect of survivin-targeted shRNA and emodin on the proliferation and invasion of ovarian cancer cells.Survivin 靶向短发夹 RNA 与大黄素联合作用对卵巢癌细胞增殖和侵袭的影响。
Anticancer Drugs. 2013 Oct;24(9):937-44. doi: 10.1097/CAD.0b013e328364efe0.

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Anti-influenza A Virus Effects and Mechanisms of Emodin and Its Analogs via Regulating PPAR/-AMPK-SIRT1 Pathway and Fatty Acid Metabolism.大黄素及其类似物通过调控 PPAR/-AMPK-SIRT1 通路和脂肪酸代谢抗流感 A 病毒的作用及机制。
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Traditional Chinese medicine combined with pulmonary drug delivery system and idiopathic pulmonary fibrosis: Rationale and therapeutic potential.中药联合肺部给药系统与特发性肺纤维化:原理与治疗潜力。
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Antitumor Research of the Active Ingredients from Traditional Chinese Medical Plant Polygonum Cuspidatum.中药虎杖有效成分的抗肿瘤研究
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Emodin Alleviates Liver Fibrosis of Mice by Reducing Infiltration of Gr1 Monocytes.大黄素通过减少Gr1单核细胞浸润减轻小鼠肝纤维化
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Tumor Preventive Efficacy of Emodin in 7,12-Dimethylbenz[a]Anthracene-Induced Oral Carcinogenesis: a Histopathological and Biochemical Approach.大黄素对7,12-二甲基苯并[a]蒽诱导的口腔癌发生的肿瘤预防作用:组织病理学和生物化学方法
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