Pediatric Department, Faculty of Medicine, Ain Shams University, Egypt.
Faculty of Medicine, El-Azhar University, Egypt.
Complement Ther Med. 2016 Apr;25:98-103. doi: 10.1016/j.ctim.2016.01.009. Epub 2016 Feb 2.
Febrile neutropenia (FN) is a common adverse effect of chemotherapy. Current management of FN is expensive and may induce side effects. Honey, as a natural honeybee product, has antioxidant, antimicrobial, immunomodulator and anticancer effects. Additionally, honey is not expensive. The aim of this study is to test the effects of a 12-week honey consumption on children with acute lymphoblastic leukemia (ALL) particularly with regard to FN.
A randomized crossover clinical trial. Forty patients of both sexes, aged 2.5-10 years, were randomized into two equal groups [intervention to control (I/C) and control to intervention (C/I)].
Children Hospital of Ain Shams University-Cairo-Egypt. The dietary intervention consisted of honey in a dose of 2.5 g//kg body weight per dose twice weekly for 12 weeks.
Febrile neutropenia in terms of frequency and duration of hospital admission.
The intervention resulted in a significant decrease of FN episodes, the number of patients admitted with FN and the duration of hospital stay. Also, honey consumption improved the levels of hemoglobin and did not produce any serious side effect. As a possible effect of honey withdrawal in the I/C group, the Hb%, the absolute neutrophil count and the platelet count decreased.
Honey intervention in a group of children with ALL resulted in positive effects on FN and hematologic parameters. Further studies that include a larger number of patients are recommended to confirm that honey, has beneficial effects, as a complementary agent, in children with ALL.
发热性中性粒细胞减少症（FN）是化疗的常见不良反应。FN 的当前治疗费用昂贵，且可能引起副作用。蜂蜜作为一种天然的蜜蜂产品，具有抗氧化、抗菌、免疫调节剂和抗癌作用。此外，蜂蜜价格低廉。本研究旨在测试 12 周蜂蜜摄入对急性淋巴细胞白血病（ALL）患儿的影响，特别是针对 FN 的影响。
一项随机交叉临床试验。40 名 2.5-10 岁的男女患儿随机分为两组（干预组至对照组（I/C）和对照组至干预组（C/I））。
埃及开罗 Ain Shams 大学儿童医院。饮食干预包括蜂蜜，剂量为 2.5 克/公斤体重，每周两次，持续 12 周。
发热性中性粒细胞减少症的频率和住院时间。
干预组 FN 发作次数、FN 住院患者人数和住院时间均显著减少。此外，蜂蜜摄入可提高血红蛋白水平，且无严重副作用。由于 I/C 组可能出现蜂蜜戒断的影响，Hb%、绝对中性粒细胞计数和血小板计数降低。
ALL 患儿中蜂蜜干预对 FN 和血液学参数有积极影响。建议进行更多患者参与的进一步研究，以确认蜂蜜作为辅助剂对 ALL 患儿具有有益作用。
