Perlman Stanley, Vijay Rahul
Department of Microbiology, BSB 3-712, University of Iowa, 51 Newton Road, Iowa City, IA 52242, USA.
Department of Microbiology, BSB 3-712, University of Iowa, 51 Newton Road, Iowa City, IA 52242, USA.
Int J Infect Dis. 2016 Jun;47:23-8. doi: 10.1016/j.ijid.2016.04.008. Epub 2016 Apr 7.
The Middle East respiratory syndrome coronavirus (MERS-CoV) has infected over 1600 individuals with nearly 600 deaths since it was first identified in human populations in 2012. No antiviral therapies or vaccines are available for its treatment or prophylaxis. Approaches to the development of MERS vaccines are discussed herein, including a summary of previous efforts to develop vaccines useful against human and non-human coronaviruses. A striking feature of MERS is the important role that camels have in transmission. Camel vaccination may be a novel approach to preventing human infection.
中东呼吸综合征冠状病毒(MERS-CoV)自2012年首次在人群中被发现以来,已感染了1600多人,造成近600人死亡。目前尚无抗病毒疗法或疫苗可用于其治疗或预防。本文讨论了MERS疫苗的研发方法,包括以往开发针对人类和非人类冠状病毒的疫苗的努力总结。MERS的一个显著特征是骆驼在传播中所起的重要作用。骆驼疫苗接种可能是预防人类感染的一种新方法。