Chen Yue
Pharmacy Department, PLA General Hospital.
Drug Discov Ther. 2016;10(2):62-73. doi: 10.5582/ddt.2016.01014. Epub 2016 Apr 11.
As the most significant cause of death worldwide, obesity has become one of the world's most important public health problems, but approved anti-obesity drugs are extremely limited. This article summarizes the feeding control circuits and regulators involved in obesity development, highlight the hypothalamus, melanocortin system and brain-gut peptide actions in this process, and the five US FDA approved anti-obesity medications in long term use, namely phentermine/topiramate, lorcaserin, naltrexone/bupropion, liraglutide and orlistat.
作为全球最重要的死因，肥胖已成为世界上最重要的公共卫生问题之一，但获批的抗肥胖药物极为有限。本文总结了肥胖发生过程中涉及的进食控制回路和调节因子，重点介绍了下丘脑、黑皮质素系统和脑肠肽在此过程中的作用，以及美国食品药品监督管理局（FDA）批准长期使用的五种抗肥胖药物，即苯丁胺/托吡酯、氯卡色林、纳曲酮/安非他酮、利拉鲁肽和奥利司他。
