Izadi Mina Sadat, Radahmadi Maryam, Ghasemi Maedeh, Rayatpour Atefeh
Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Adv Biomed Res. 2018 Aug 29;7:118. doi: 10.4103/abr.abr_28_18. eCollection 2018.
Exposure to psychological stresses can be a reason for obesity. Therefore, identifying the effective nutritional mechanisms such as feeding markers is of high necessity for the psychological stress conditions. Hence, the present study investigates the effects of subchronic isolation and social stresses on food intake, body weight differences (BWD), and levels of leptin, ghrelin, and glucose in rats.
Eighteen male rats were randomly allocated into three groups: control (Co), isolation stress (IS), and social stress (SS) groups. Rats were under stresses for 7 days. The food intake (for three continuous hours after 16-18 h of food deprivation), BWD, levels of ghrelin, leptin, and glucose were measured.
The results showed that the food intake significantly ( < 0.05) reduced during the 1 h in the SS group compared to the Co group. At the 2 h, the food intake significantly ( < 0.001 and < 0.01, respectively) decreased in the IS group compared to the Co and SS groups. The cumulative food intake and body weight were significantly ( < 0.05) reduced in the IS group compared to the Co group. The serum ghrelin level significantly reduced in the IS group compared to the Co group.
The subchronic psychological stresses led to a reduction in food intake by the reduction of serum ghrelin levels. It seems that ghrelin might have a more fundamental role in the food intake with respect to the leptin and glucose levels in subchronic stress condition. Furthermore, the decreased body weight justified the reduction of food intake, particularly in subchronic isolation stress.
暴露于心理压力下可能是肥胖的一个原因。因此，识别诸如进食标志物等有效的营养机制对于心理压力状况而言非常必要。因此，本研究调查了亚慢性隔离和社会压力对大鼠食物摄入量、体重差异（BWD）以及瘦素、胃饥饿素和葡萄糖水平的影响。
18只雄性大鼠被随机分为三组：对照组（Co）、隔离应激组（IS）和社会应激组（SS）。大鼠处于应激状态7天。测量食物摄入量（禁食16 - 18小时后连续3小时）、体重差异、胃饥饿素、瘦素和葡萄糖水平。
结果显示，与Co组相比，SS组在1小时内食物摄入量显著降低（<0.05）。在2小时时，与Co组和SS组相比，IS组的食物摄入量分别显著降低（<0.001和<0.01）。与Co组相比，IS组的累积食物摄入量和体重显著降低（<0.05）。与Co组相比，IS组血清胃饥饿素水平显著降低。
亚慢性心理应激通过降低血清胃饥饿素水平导致食物摄入量减少。在亚慢性应激条件下，就瘦素和葡萄糖水平而言，胃饥饿素似乎在食物摄入中可能具有更重要的作用。此外，体重下降证明了食物摄入量的减少是合理的，特别是在亚慢性隔离应激中。
