Dinardi Ricardo Reis, de Andrade Cláudia Ribeiro, Martins-Costa Hugo Cesar, Ibiapina Cássio da Cunha
Pediatric Pulmonology Unit, University Hospital, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Pediatric Pulmonology Unit, University Hospital, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Int J Pediatr Otorhinolaryngol. 2016 May;84:37-42. doi: 10.1016/j.ijporl.2016.02.023. Epub 2016 Feb 27.
Nasal dilators are being developed for the purpose of increasing air flow in the nasal valve. The aim of this study is to evaluate the use of the internal nasal dilator (IND) by adolescent athletes.
A double-blind, crossover clinical trial in which we evaluated 54 adolescents using experimental and placebo INDs, submitted to a cardio-respiratory test in randomized order. The predicted values for the peak nasal inspiratory flow (PNIF) were obtained and the intensity of dyspnea was evaluated using the visual analog scale method after the race.
In relation to PNIF (% predicted), when participants used the experimental IND, significantly higher means were found in comparison with the placebo (104.27±24.67L/min and 97.73±25.61L/min, respectively) (p=0.010). There were no significant differences observed in terms of heart rate (HR), pulse oximetry (SpO2) and maximal oxygen uptake (VO2max), before and after the cardio-respiratory test. There was also no significant difference (p>0.05) between the use of experimental and placebo INDs on dyspnea scale measurements after completion of the cardio-respiratory test.
Results suggested that the Airmax® IND improves nasal patency, as measured by PNIF, in healthy adolescent athletes. There was no statistically significant difference in the values for heart rate and SpO2. There was also no difference between the conditions tested for the mean VO2max. Further studies should be conducted to evaluate the effect of IND in adolescent athletes with chronic diseases, such as asthma and allergic rhinitis, and also using other cardio-respiratory assessment methods.
正在研发鼻扩张器以增加鼻瓣处的气流。本研究的目的是评估青少年运动员使用鼻内扩张器（IND）的情况。
一项双盲交叉临床试验，我们使用实验性和安慰剂IND对54名青少年进行评估，以随机顺序进行心肺测试。获取鼻吸气峰值流量（PNIF）的预测值，并在比赛后使用视觉模拟量表法评估呼吸困难的强度。
关于PNIF（预测百分比），当参与者使用实验性IND时，与安慰剂相比，发现平均值显著更高（分别为104.27±24.67L/分钟和97.73±25.61L/分钟）（p = 0.010）。在心肺测试前后，心率（HR）、脉搏血氧饱和度（SpO2）和最大摄氧量（VO2max）方面未观察到显著差异。在心肺测试完成后，使用实验性和安慰剂IND在呼吸困难量表测量方面也没有显著差异（p>0.05）。
结果表明，通过PNIF测量，Airmax® IND可改善健康青少年运动员的鼻腔通畅度。心率和SpO2值在统计学上没有显著差异。在平均VO2max的测试条件之间也没有差异。应进行进一步研究以评估IND对患有慢性疾病（如哮喘和过敏性鼻炎）的青少年运动员的影响，以及使用其他心肺评估方法的效果。
