Allergy Center, CUF Descobertas Hospital and CUF Infante Santo Hospital, Lisbon, Portugal.
Rhinology. 2018 Sep 1;56(3):288-296. doi: 10.4193/Rhin17.229.
Rhinitis and asthma frequently coexist. Peak nasal inspiratory flow (PNIF) objectively evaluates nasal obstruction. Lower airway flow's impact on PNIF has seldom been analysed in children. We aimed to study the associations between PNIF and: 1)forced expiratory volume in one second (FEV1) and peak expiratory flow (PEF) in children with allergic rhinitis and asthma and healthy controls; 2)allergic rhinitis and asthma control subjective evaluation.
Sequential assessments of PNIF before and after nasal decongestion and spirometry with bronchodilation test were performed in 65 children (6-12 years) with allergic rhinitis and asthma, and 24 gender, age-matched healthy controls. The Control of Allergic Rhinitis and Asthma Test in children (CARATkids) was used for control assessment. Associations were investigated by multiple linear regression models.
Baseline and decongested PNIF correlated with baseline and post-bronchodilation FEV1 and PEF, observed independently of rhinitis and asthma diagnosis. The best model for PNIF included PEF, age and gender. No association was found between PNIF and CARATkids scores, except for nasal obstruction self-report.
In school-aged children, besides age and gender, PEF values should ideally be known to interpret PNIF values. PNIF can be complementary to subjective control assessment in children with allergic rhinitis and asthma.
鼻炎和哮喘经常同时存在。峰值鼻吸气流量（PNIF）客观评估鼻阻塞。很少分析过儿童中下气道流量对 PNIF 的影响。我们旨在研究以下因素与 PNIF 的相关性：1）过敏性鼻炎和哮喘儿童以及健康对照者的一秒用力呼气容积（FEV1）和呼气峰流量（PEF）；2）过敏性鼻炎和哮喘控制的主观评估。
对 65 名患有过敏性鼻炎和哮喘的儿童（6-12 岁）和 24 名性别、年龄匹配的健康对照者进行了鼻减充血前后的 PNIF 和支气管扩张试验的肺活量测定评估。采用儿童过敏性鼻炎和哮喘控制测试（CARATkids）进行对照评估。通过多元线性回归模型研究相关性。
基线和减充血后的 PNIF 与基线和支气管扩张后 FEV1 和 PEF 相关，与过敏性鼻炎和哮喘的诊断独立相关。PNIF 的最佳模型包括 PEF、年龄和性别。除了鼻阻塞的自我报告外，PNIF 与 CARATkids 评分之间无相关性。
在学龄儿童中，除了年龄和性别外，理想情况下还应了解 PEF 值以解释 PNIF 值。PNIF 可作为过敏性鼻炎和哮喘儿童主观控制评估的补充。
