Kim Michele M, Penjweini Rozhin, Gemmell Nathan R, Veilleux Israel, McCarthy Aongus, Buller Gerald, Hadfield Robert H, Wilson Brian C, Zhu Timothy C
Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA; Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA, USA.
Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA.
Proc SPIE Int Soc Opt Eng. 2016 Feb 13;9694. doi: 10.1117/12.2213236. Epub 2016 Mar 1.
An explicit dosimetry model has been developed to calculate the apparent reacted concentration ([]) in an model. In the model, a macroscopic quantity, , is introduced to account for oxygen perfusion to the medium during PDT. In this study, the SOED model is extended for PDT treatment in phantom conditions where vasculature is not present; the oxygen perfusion is achieved through the air-phantom interface instead. The solution of the SOED model is obtained by solving the coupled photochemical rate equations incorporating oxygen perfusion through the air-liquid interface. Experiments were performed for two photosensitizers (PS), Rose Bengal (RB) and Photofrin (PH), in solution, using SOED and SOLD measurements to determine both the instantaneous [O] as well as cumulative [O] concentrations, where [O] = (1/) · ∫[O]. The PS concentrations varied between 10 and 100 mM for RB and ~200 mM for Photofrin. The resulting magnitudes of [O] were compared between SOED and SOLD.
已开发出一种显式剂量学模型，用于计算模型中的表观反应浓度（[]）。在该模型中，引入了一个宏观量来考虑光动力疗法（PDT）期间氧气向介质的灌注。在本研究中，将表面氧增强扩散（SOED）模型扩展到不存在脉管系统的体模条件下的PDT治疗；氧气灌注是通过气-体模界面实现的。通过求解包含通过气-液界面的氧气灌注的耦合光化学速率方程来获得SOED模型的解。使用SOED和SOLD测量方法，对溶液中的两种光敏剂（PS），即孟加拉玫瑰红（RB）和血卟啉（PH）进行了实验，以确定瞬时[O]以及累积[O]浓度，其中[O] = (1/)·∫[O]。RB的PS浓度在10至100 mM之间变化，血卟啉的PS浓度约为200 mM。比较了SOED和SOLD之间所得的[O]大小。
