通过与单线态氧发光剂量测定（SOLD）系统进行比对，对光动力疗法（PDT）的单线态氧显式剂量测定（SOED）进行可行性研究。
A feasibility study of singlet oxygen explicit dosmietry (SOED) of PDT by intercomparison with a singlet oxygen luminescence dosimetry (SOLD) system.
作者信息
Kim Michele M, Penjweini Rozhin, Gemmell Nathan R, Veilleux Israel, McCarthy Aongus, Buller Gerald, Hadfield Robert H, Wilson Brian C, Zhu Timothy C
机构信息
Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA; Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA, USA.
Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA.
出版信息
Proc SPIE Int Soc Opt Eng. 2016 Feb 13;9694. doi: 10.1117/12.2213236. Epub 2016 Mar 1.
An explicit dosimetry model has been developed to calculate the apparent reacted concentration ([]) in an model. In the model, a macroscopic quantity, , is introduced to account for oxygen perfusion to the medium during PDT. In this study, the SOED model is extended for PDT treatment in phantom conditions where vasculature is not present; the oxygen perfusion is achieved through the air-phantom interface instead. The solution of the SOED model is obtained by solving the coupled photochemical rate equations incorporating oxygen perfusion through the air-liquid interface. Experiments were performed for two photosensitizers (PS), Rose Bengal (RB) and Photofrin (PH), in solution, using SOED and SOLD measurements to determine both the instantaneous [O] as well as cumulative [O] concentrations, where [O] = (1/) · ∫[O]. The PS concentrations varied between 10 and 100 mM for RB and ~200 mM for Photofrin. The resulting magnitudes of [O] were compared between SOED and SOLD.
已开发出一种显式剂量学模型，用于计算模型中的表观反应浓度（[]）。在该模型中，引入了一个宏观量来考虑光动力疗法（PDT）期间氧气向介质的灌注。在本研究中，将表面氧增强扩散（SOED）模型扩展到不存在脉管系统的体模条件下的PDT治疗；氧气灌注是通过气-体模界面实现的。通过求解包含通过气-液界面的氧气灌注的耦合光化学速率方程来获得SOED模型的解。使用SOED和SOLD测量方法，对溶液中的两种光敏剂（PS），即孟加拉玫瑰红（RB）和血卟啉（PH）进行了实验，以确定瞬时[O]以及累积[O]浓度，其中[O] = (1/)·∫[O]。RB的PS浓度在10至100 mM之间变化，血卟啉的PS浓度约为200 mM。比较了SOED和SOLD之间所得的[O]大小。
Zotero 插件