用于实验性角膜孟加拉玫瑰红光动力抗菌治疗的单线态氧发光检测。
Detection of singlet oxygen luminescence for experimental corneal rose bengal photodynamic antimicrobial therapy.
作者信息
Peterson Jeffrey C, Arrieta Esdras, Ruggeri Marco, Silgado Juan D, Mintz Keenan J, Weisson Ernesto H, Leblanc Roger M, Kochevar Irene, Manns Fabrice, Parel Jean-Marie
机构信息
Ophthalmic Biophysics Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 1638 NW 10th Ave, Miami, FL 33136, USA.
Department of Biomedical Engineering, University of Miami, 1251 Memorial Dr, Coral Gables, FL 33146, USA.
出版信息
Biomed Opt Express. 2020 Dec 10;12(1):272-287. doi: 10.1364/BOE.405601. eCollection 2021 Jan 1.
Abstract
Rose bengal photodynamic antimicrobial therapy (RB-PDAT) treats corneal infection by activating rose bengal (RB) with green light to produce singlet oxygen (O). Singlet oxygen dosimetry can help optimize treatment parameters. We present a O dosimeter for detection of O generated during experimental RB-PDAT. The system uses a 520 nm laser and an InGaAs photoreceiver with bandpass filters to detect O luminescence during irradiation. The system was validated in RB solutions and in human donor eyes. The results demonstrate the feasibility of O dosimetry in an experimental model of RB-PDAT in the cornea.
摘要
孟加拉玫瑰红光动力抗菌疗法（RB-PDAT）通过用绿光激活孟加拉玫瑰红（RB）以产生单线态氧（O）来治疗角膜感染。单线态氧剂量测定有助于优化治疗参数。我们展示了一种用于检测实验性RB-PDAT过程中产生的O的剂量计。该系统使用520 nm激光和带有带通滤波器的铟镓砷光接收器来检测照射期间的O发光。该系统在RB溶液和人类供体眼中得到了验证。结果证明了在角膜RB-PDAT实验模型中进行O剂量测定的可行性。
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