Cai Yu, Tang Qianyun, Wu Xiujuan, Si Weili, Zhang Qi, Huang Wei, Dong Xiaochen
Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), and ‡School of Pharmaceutical Sciences, Nanjing Tech University (NanjingTech) , 30 South Puzhu Road, Nanjing 211816, China.
ACS Appl Mater Interfaces. 2016 May 4;8(17):10737-42. doi: 10.1021/acsami.6b01533. Epub 2016 Apr 25.
Novel photosensitizers with high reactive oxygen species generation and precise targeting to tumors are crucial for photodynamic therapy (PDT). Here, a bromo-substituted diketopyrrolopyrrole derivative (2,5-bis(6-bromohexyl)-3,6-bis(5-bromothiophene-2-yl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione)-grafted hyaluronic acid is synthesized, which presents excellent targeting and PDT efficiency both in vitro and in vivo.
