Powers R E, O'Connor D T, Price D L
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD.
Brain Res. 1989 Feb 27;481(1):194-9. doi: 10.1016/0006-8993(89)90504-0.
Thin, beaded axons, immunostained with antisera to human dopamine beta-hydroxylase (DBH), were present in all layers of the anterior vermis of human cerebellum. This plexus appears similar to that described in rodents and provides information complementary to receptor autoradiographic studies that show significant noradrenergic innervation of mammalian cerebellum. Moreover, in two aged controls, we demonstrated abnormal, swollen, tortuous axons not visualized in young controls.
用抗人多巴胺β-羟化酶（DBH）抗血清进行免疫染色后，可见细的、串珠状轴突存在于人类小脑蚓部前部的所有层中。这个神经丛看起来与在啮齿动物中描述的相似，并提供了与受体放射自显影研究互补的信息，该研究表明哺乳动物小脑有显著的去甲肾上腺素能神经支配。此外，在两名老年对照者中，我们发现了年轻对照者中未见到的异常、肿胀、扭曲的轴突。
