Powers R E, Struble R G, Casanova M F, O'Connor D T, Kitt C A, Price D L
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Neuroscience. 1988 May;25(2):401-17. doi: 10.1016/0306-4522(88)90248-5.
Immunocytochemical studies, using an antibody directed against human dopamine beta-hydroxylase, identified an extensive plexus of noradrenergic axons/terminals in normal human hippocampus. In hippocampi of individuals with Alzheimer's disease, the density of noradrenergic innervation was reduced and abnormal noradrenergic axons, which exhibited multifocal enlargements, were present in the neuropil. Some of these neurites were clustered around deposits of amyloid (senile plaques), and these abnormalities were most common in CA3-4, a region normally showing a relatively high density of noradrenergic terminals. This investigation provides direct evidence for structural abnormalities of noradrenergic axons/nerve terminals in hippocampi of individuals with Alzheimer's disease.
免疫细胞化学研究使用针对人多巴胺β-羟化酶的抗体，在正常人类海马体中鉴定出广泛的去甲肾上腺素能轴突/终末丛。在阿尔茨海默病患者的海马体中，去甲肾上腺素能神经支配密度降低，并且在神经毡中存在表现为多灶性膨大的异常去甲肾上腺素能轴突。其中一些神经突聚集在淀粉样蛋白（老年斑）沉积物周围，并且这些异常在CA3 - 4区域最为常见，该区域通常显示出相对较高密度的去甲肾上腺素能终末。这项研究为阿尔茨海默病患者海马体中去甲肾上腺素能轴突/神经终末的结构异常提供了直接证据。
