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切断和挤压损伤后大鼠感觉神经元中速激肽和血管活性肠肽基因表达的相互调节

Reciprocal regulation of tachykinin- and vasoactive intestinal peptide-gene expression in rat sensory neurones following cut and crush injury.

作者信息

Nielsch U, Keen P

机构信息

Department of Pharmacology, Medical School, University of Bristol, U.K.

出版信息

Brain Res. 1989 Feb 27;481(1):25-30. doi: 10.1016/0006-8993(89)90481-2.

DOI:10.1016/0006-8993(89)90481-2
PMID:2706464
Abstract

The relative abundance of preprotachykinin- (PPT), actin- and vasoactive intestinal peptide- (VIP) mRNA's was measured in L5 dorsal root ganglia of rats after resecting or crushing the sciatic nerve. PPT-mRNA levels fell to 40% of control values 3, 6 and 9 days following nerve resection. Crushing produced a lesser fall at 3 and 6 days with a partial recovery at 9 days. Following resection actin-mRNA levels transiently rose to twice control values and had returned to normal by day 9. VIP-mRNA was not detectable in control ganglia but increasing amounts of VIP-mRNA were present 3, 6 and 9 days after nerve injury. The results are discussed in terms of the control mechanisms operating.

摘要

在切除或挤压大鼠坐骨神经后，测量了L5背根神经节中前速激肽原（PPT）、肌动蛋白和血管活性肠肽（VIP）mRNA的相对丰度。神经切除后3、6和9天，PPT - mRNA水平降至对照值的40%。挤压在3天和6天时下降幅度较小，9天时部分恢复。切除后，肌动蛋白 - mRNA水平短暂升至对照值的两倍，并在第9天恢复正常。对照神经节中未检测到VIP - mRNA，但神经损伤后3、6和9天，VIP - mRNA的量不断增加。根据所起作用的控制机制对结果进行了讨论。

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