Taylor S J, Greenfield S A
University Laboratory of Pharmacology, Oxford, U.K.
Brain Res. 1989 Mar 20;482(2):356-8. doi: 10.1016/0006-8993(89)91200-6.
A soluble form of acetylcholinesterase is released from the substantia nigra in both a spontaneous and drug-induced fashion. The aim of this study was to see whether this phenomenon was also sensitive to a non-pharmacological event. During electrical stimulation of the intact sciatic nerve, there was an increase in the activity of acetylcholinesterase, measured in perfusates of the guinea-pig substantia nigra in vivo. This increase was not due to spontaneous fluctuations in acetylcholinesterase release, plasma contamination, tissue damage or release of acetylcholinesterase from a non-specific site. The possible pathways mediating this phenomenon are discussed.
一种可溶性乙酰胆碱酯酶以自发和药物诱导的方式从黑质释放。本研究的目的是观察这种现象是否也对非药理学事件敏感。在完整坐骨神经的电刺激过程中，在豚鼠黑质体内灌注液中测得的乙酰胆碱酯酶活性增加。这种增加不是由于乙酰胆碱酯酶释放的自发波动、血浆污染、组织损伤或非特异性部位乙酰胆碱酯酶的释放。文中讨论了介导这一现象的可能途径。
