女性生殖道炎症、HIV合并感染及持续性黏膜人乳头瘤病毒（HPV）感染
Female genital tract inflammation, HIV co-infection and persistent mucosal Human Papillomavirus (HPV) infections.
作者信息
Kriek Jean-Mari, Jaumdally Shameem Z, Masson Lindi, Little Francesca, Mbulawa Zizipho, Gumbi Pamela P, Barnabas Shaun L, Moodley Jennifer, Denny Lynette, Coetzee David, Williamson Anna-Lise, Passmore Jo-Ann S
机构信息
Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Department of Statistical Science, University of Cape Town, Cape Town, South Africa.
出版信息
Virology. 2016 Jun;493:247-54. doi: 10.1016/j.virol.2016.03.022. Epub 2016 Apr 11.
BACKGROUND
Persistent genital infections with high-risk HPV types increase risk of cervical disease and cancer. Since genital inflammation increases HIV acquisition risk and cancer progression, we evaluated whether HPV infection induces cytokine expression in the reproductive tract.
METHODS
Genital cytokines concentrations were measured in 93 HIV-infected and 72 uninfected women. HPV typing was done by Roche Linear array. Persistence and clearance of HPV were evaluated using longitudinal data.
RESULTS
Infection with HPV did not influence genital cytokine concentrations. In contrast, HIV-infected women had higher IL-1α, IL-6, IL-8, IP-10, MCP-1 and G-CSF concentrations compared to HIV-uninfected women, and HPV-infections that were more prevalent, persistent and multi-type.
CONCLUSION
HPV did not influence inflammatory cytokine levels in the genital tract, although immune suppression may favor persistence.
背景
高危型人乳头瘤病毒（HPV）持续的生殖器感染会增加患宫颈疾病和癌症的风险。由于生殖器炎症会增加感染HIV的风险以及癌症进展，我们评估了HPV感染是否会诱导生殖道中细胞因子的表达。
方法
对93名感染HIV的女性和72名未感染HIV的女性测量其生殖器细胞因子浓度。采用罗氏线性阵列进行HPV分型。利用纵向数据评估HPV的持续感染和清除情况。
结果
HPV感染不影响生殖器细胞因子浓度。相比之下，与未感染HIV的女性相比，感染HIV的女性白细胞介素-1α（IL-1α）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、干扰素诱导蛋白10（IP-10）、单核细胞趋化蛋白-1（MCP-1）和粒细胞集落刺激因子（G-CSF）浓度更高，且HPV感染更普遍、持续时间更长且为多型感染。
结论
HPV不影响生殖道中的炎性细胞因子水平，尽管免疫抑制可能有利于HPV持续感染。
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