基于膜的有丝分裂纺锤体组装机制。
Membrane-based mechanisms of mitotic spindle assembly.
作者信息
Schweizer Nina, Maiato Helder
机构信息
Chromosome Instability & Dynamics Laboratory; Instituto de Biologia Molecular e Celular; Universidade do Porto; Porto, Portugal; Instituto de Investigação e Inovação em Saúde - i3S; Universidade do Porto; Porto, Portugal; Present address: Institute for Research in Biomedicine (IRB Barcelona); C/ Baldiri Reixac 10, 08028 Barcelona, Spain.
Chromosome Instability & Dynamics Laboratory; Instituto de Biologia Molecular e Celular; Universidade do Porto; Porto, Portugal; Instituto de Investigação e Inovação em Saúde - i3S; Universidade do Porto; Porto, Portugal; Cell Division Unit; Department of Experimental Biology; Faculdade de Medicina; Universidade do Porto; Alameda Prof. Hernâni Monteiro; Porto, Portugal.
出版信息
Commun Integr Biol. 2015 Nov 10;8(6):e1112473. doi: 10.1080/19420889.2015.1112473. eCollection 2015 Nov-Dec.
Chromosome segregation during mitosis is mediated by the mitotic spindle. Formation of this microtubular structure relies on distinct processes such as microtubule nucleation and growth and the consequent focusing of these filaments into spindle poles. Here, we discuss our recent finding that a size-exclusion spindle envelope promotes mitotic fidelity in Drosophila cells in light of distinct spindle assembly mechanisms.
有丝分裂期间的染色体分离由有丝分裂纺锤体介导。这种微管结构的形成依赖于不同的过程，如微管成核和生长，以及随后将这些细丝聚焦到纺锤体极。在此，我们根据不同的纺锤体组装机制，讨论我们最近的发现：一种尺寸排阻纺锤体包膜可促进果蝇细胞中的有丝分裂保真度。
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