Nakaguchi Hiroshi, Matsuno Akira, Okubo Toshiyuki, Hoya Katsumi
Department of Neurosurgery, Mitsui Memorial Hospital, Tokyo, Japan.
Department of Neurosurgery, Teikyo University Hospital, Tokyo, Japan.
J Stroke Cerebrovasc Dis. 2016 Jul;25(7):1678-1682. doi: 10.1016/j.jstrokecerebrovasdis.2016.01.020. Epub 2016 Apr 7.
In aging societies such as that of Japan, it is important to characterize lifestyle-related factors that minimize the occurrence of silent brain infarction (SBI) among the middle aged population for preventing vascular dementia in older age. Little is known about the relationship between amount of coffee consumption and SBI.
To assess the association between the amount of coffee consumption and SBI in middle age, we statistically analyzed magnetic resonance imaging findings and data from questionnaires of consecutive 242 healthy Japanese individuals whose ages were less than 65 years and who participated in a medical brain-screening program at Teikyo University Chiba Medical Center from June 2008 to June 2009.
In comparison with noncoffee drinkers (reference group), coffee drinkers who took 3-4 cups/day and 5 or more cups/day had a statistically lower incidence of SBI (.22, .07-.64, .004 and .43, .19-.99, .043, respectively). Upward logistic regression analysis indicated that SBI was influenced by 3 factors: coffee intake of 3 or more cups/day (.43, .22.84, .014), history of hypertension (4.2, 2.08.8, .0001), and unemployment (2.1, 1.0~4.4, .037). As for consecutive 62 participants whose ages were 65 years or older in the same period, logistic regression analysis did not indicate that drinking coffee affected SBI incidence.
Our report demonstrated that SBI was observed less frequently in middle aged Japanese who consumed 3 cups or more of coffee per day. To avoid senile dementia and/or symptomatic infarction in older age, the middle aged individuals might have to drink more than 3 cups of coffee every day.
在日本这样的老龄化社会中，确定与生活方式相关的因素对于预防老年人血管性痴呆至关重要，这些因素可将中年人群中无症状脑梗死（SBI）的发生率降至最低。目前对于咖啡饮用量与SBI之间的关系知之甚少。
为了评估中年人群中咖啡饮用量与SBI之间的关联，我们对242名年龄小于65岁、于2008年6月至2009年6月期间参加帝京大学千叶医学中心脑部医学筛查项目的连续健康日本个体的磁共振成像结果和问卷调查数据进行了统计分析。
与不喝咖啡者（参照组）相比，每天饮用3 - 4杯和5杯及以上咖啡的饮用者SBI发生率在统计学上较低（分别为0.22，95%置信区间0.07 - 0.64，P = 0.004；以及0.43，95%置信区间0.19 - 0.99，P = 0.043）。向上逻辑回归分析表明，SBI受3个因素影响：每天饮用3杯及以上咖啡（比值比0.43，95%置信区间0.22 - 0.84，P = 0.014）、高血压病史（4.2，95%置信区间2.0 - 8.8，P = 0.0001）和失业（2.1，95%置信区间1.0 - 4.4，P = 0.037）。对于同期连续62名年龄在65岁及以上的参与者，逻辑回归分析未表明喝咖啡会影响SBI发生率。
我们的报告表明，在中年日本人群中，每天饮用3杯或更多咖啡的人群中SBI的发生率较低。为了避免老年时患老年痴呆症和/或症状性梗死，中年个体可能需要每天饮用超过3杯咖啡。
