Department of Biomedical and Biotechnological Sciences, University of Catania, Via Santa Sofia 97, 95123 Catania, Italy.
Department of Surgery and Medical-Surgery Specialties, University of Catania, Via Santa Sofia 78, 95123 Catania, Italy.
Nutrients. 2021 Feb 6;13(2):536. doi: 10.3390/nu13020536.
To date, interest in the role of coffee intake in the occurrence and course of age-related neurological and neuropsychiatric disorders has provided an inconclusive effect. Moreover, no study has evaluated mocha coffee consumption in subjects with mild vascular cognitive impairment and late-onset depression. We assessed the association between different quantities of mocha coffee intake over the last year and cognitive and mood performance in a homogeneous sample of 300 non-demented elderly Italian subjects with subcortical ischemic vascular disease. Mini Mental State Examination (MMSE), Stroop Colour-Word Interference Test (Stroop T), 17-items Hamilton Depression Rating Scalfe (HDRS), Activities of Daily Living (ADL), and Instrumental ADL were the outcome measures. MMSE, HDRS, and Stroop T were independently and significantly associated with coffee consumption, i.e., better scores with increasing intake. At the post-hoc analyses, it was found that the group with a moderate intake (two cups/day) had similar values compared to the heavy drinkers (≥three cups/day), with the exception of MMSE. Daily mocha coffee intake was associated with higher cognitive and mood status, with a significant dose-response association even with moderate consumption. This might have translational implications for the identification of modifiable factors for vascular dementia and geriatric depression.
迄今为止，人们对咖啡摄入在与年龄相关的神经和神经精神疾病的发生和病程中的作用的兴趣提供了一个不确定的影响。此外，没有研究评估摩卡咖啡在轻度血管性认知障碍和迟发性抑郁症患者中的消耗。我们评估了过去一年中不同数量的摩卡咖啡摄入与认知和情绪表现之间的关联，在一个由 300 名非痴呆的意大利皮质下缺血性血管疾病老年人组成的同质样本中进行了评估。简易精神状态检查 (MMSE)、Stroop 颜色-文字干扰测试 (Stroop T)、17 项汉密尔顿抑郁评定量表 (HDRS)、日常生活活动 (ADL) 和工具性日常生活活动 (IADL) 是结果测量。MMSE、HDRS 和 Stroop T 与咖啡摄入量独立且显著相关，即摄入量增加，得分更好。在事后分析中，发现中等摄入量（每天两杯）组与大量饮酒者（每天≥三杯）的评分相似，除了 MMSE 之外。每天饮用摩卡咖啡与更高的认知和情绪状态相关，即使中等摄入量也存在显著的剂量反应关系。这可能对识别血管性痴呆和老年抑郁症的可改变因素具有转化意义。
