神经母细胞瘤细胞周期中的微粘度调节
Microviscosity modulation during the cell cycle of neuroblastoma cells.
作者信息
de Laat S W, van der Saag P T, Shinitzky M
出版信息
Proc Natl Acad Sci U S A. 1977 Oct;74(10):4458-61. doi: 10.1073/pnas.74.10.4458.
Abstract
Microviscosity (n) of the cell membrane lipid layer was determined in synchronized C1300 mouse neuroblastoma cells (clone Neuro-2A) by fluorescence polarization of 1,6-diphenystratum. The determined n value was maximal in mitosis, decreased markedly in the G1 phase, remained constant at a low level during the S phase, and increased again during the G2 phase. These findings imply a direct role of the cell membrane fluidity in regulation of the cell cycle.
摘要
通过1,6 - 二苯基己三烯的荧光偏振测定同步化的C1300小鼠神经母细胞瘤细胞（克隆Neuro - 2A）细胞膜脂质层的微粘度（n）。所测定的n值在有丝分裂时最大，在G1期显著降低，在S期维持在低水平且保持恒定，在G2期又再次升高。这些发现表明细胞膜流动性在细胞周期调控中具有直接作用。
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