局部晚期肺癌患者姑息性放疗的辐射剂量及完成情况对生存的影响

Impact of the Radiation Dose and Completion of Palliative Radiotherapy on Survival in Patients Treated for Locally Advanced Lung Cancer.

作者信息

Janssen Stefan, Kaesmann Lukas, Schild Steven E, Rades Dirk

机构信息

Department of Radiation Oncology, University of Lübeck, Lübeck, Germany Medical Practice for Radiotherapy and Radiation Oncology, Hannover, Germany.

Department of Radiation Oncology, University of Lübeck, Lübeck, Germany.

出版信息

Anticancer Res. 2016 Apr;36(4):1825-8.

PMID:27069165

Abstract

AIM

To compare three total radiation dose levels for their impact on survival in patients receiving palliative radiotherapy (RT) for locally advanced lung cancer.

PATIENTS AND METHODS

Radiation dose (equivalent dose in 2 Gy fractions=EQD2: 31-40 Gy vs. 41-46 Gy vs. 47-52 Gy), completion of RT as planned, plus nine factors were analyzed for survival in 125 patients.

RESULTS

On multivariate analysis, EQD2 47-52 Gy (p=0.018), completion of planned RT (p=0.002), lower T-category (p=0.027) and lower N-category (p=0.008) were positively associated with survival. Thirty-six patients (29%) could not receive the complete planned RT dose, 19% in the 31-40 Gy group, 36% in the 41-46 Gy group and 31% in the 47-52 Gy group, respectively. Six-month survival rates of these patients were 0%, 18% and 18%, respectively.

CONCLUSION

Higher RT doses resulted in significantly better survival than lower doses. The favorable results were impaired when the planned treatment could not be completed.

摘要

目的

比较三种总辐射剂量水平对局部晚期肺癌接受姑息性放疗（RT）患者生存的影响。

患者与方法

分析了辐射剂量（2 Gy 分次等效剂量=EQD2：31 - 40 Gy 对比 41 - 46 Gy 对比 47 - 52 Gy）、按计划完成放疗情况，以及125例患者生存情况的九个因素。

结果

多因素分析显示，EQD2 为 47 - 52 Gy（p = 0.018）、按计划完成放疗（p = 0.002）、较低的 T 分期（p = 0.027）和较低的 N 分期（p = 0.008）与生存呈正相关。36例患者（29%）未能接受完整的计划放疗剂量，31 - 40 Gy组为19%，41 - 46 Gy组为36%，47 - 52 Gy组为31%。这些患者的六个月生存率分别为0%、18%和18%。