De Schutter E
Department of Neurology, University of Antwerp, Belgium.
Comput Biol Med. 1989;19(2):71-81. doi: 10.1016/0010-4825(89)90001-2.
A software package 'Nodus' for simulation and development of compartmental models of neurons is described. Passive or excitable membranes with voltage dependent ion conductances or synaptic conductances can be modeled. Detailed simulations of morphology and electrophysiology of neurons are possible. Neurophysiological experiments like voltage clamps and complex current injections can be simulated. Two integration methods are available: a fast hybrid method and an accurate fifth order Runge-Kutta method, with variable time steps. Nodus is implemented on Apple Macintosh microcomputers, with the standard user interface and interactive graphics. Simulations of simple test models demonstrate the accuracy and computation speed of the application.
描述了一个用于神经元房室模型模拟与开发的软件包“Nodus”。可以对具有电压依赖性离子电导或突触电导的被动或可兴奋膜进行建模。能够对神经元的形态和电生理进行详细模拟。可以模拟电压钳和复杂电流注入等神经生理学实验。有两种积分方法可供使用：一种快速混合方法和一种精确的五阶龙格 - 库塔方法，时间步长可变。Nodus在苹果麦金塔微型计算机上实现，具有标准用户界面和交互式图形。简单测试模型的模拟展示了该应用程序的准确性和计算速度。
