Moludi Jalal, Keshavarz Seyedali, Tabaee Ali Sadeghpour, Safiri Saeid, Pakzad Reza
Department of Biochemistry and Diet Therapy, Faculty of Nutrition, Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
J Cardiovasc Thorac Res. 2016;8(1):1-7. doi: 10.15171/jcvtr.2016.01. Epub 2016 Mar 14.
Coronary artery bypass surgery (CABG) is associated with ischemia-reperfusion injury and tissue damage. CoQ10 as an antioxidant has an important role and may have cardio-protective effects after myocardial dysfunction and CABG. We aimed to evaluate whether CoQ10 has a myocardial cardio protective impact on cardiac biomarkers after CABG.
In this double-blind study, 80 patients with coronary artery disease (CAD) who underwent CABG surgery were divided into intervention and control groups and received Q10 supplement or placebo, respectively. The surgical characteristics of the patients in the two groups were similar. The intervention group received 150 mg of Q10 supplement per day for 7 days before the surgery. The control group received placebo capsule. After operation the inter- and intra-group blood levels of CK-MB and troponin, before and after supplementation and 12 hours after the CABG, and postoperative outcomes such as intensive care unit (ICU) stay and hospital stay were compared.
In this study, 40 subjects were located in each group. The participation rate was 97.5% and men and women accounted for 52.5% and 47.5% respectively. The mean age of the subjects was 58.17 ± 8.55. The two groups were not significantly different in terms of basic variables. Within-group comparison showed a significant increase in the level of troponin enzymes over time (P < 0.001) and CK-MB (P < 0.001). However, between-group comparison showed no significant difference between the two groups in terms of CK-MB (P = 0.384) and troponin (P = 0.115). In the end, no interaction was observed between the intervention and time on CK-MB (P = 0.095) and troponin (P = 0.198) variables.
Q10 supplementation 7 days before surgery was not effective in reducing CK-MB and troponin after CABG.
冠状动脉搭桥手术（CABG）与缺血再灌注损伤及组织损伤相关。辅酶Q10作为一种抗氧化剂具有重要作用，在心肌功能障碍和CABG术后可能具有心脏保护作用。我们旨在评估辅酶Q10对CABG术后心脏生物标志物是否具有心肌保护作用。
在这项双盲研究中，80例行CABG手术的冠心病（CAD）患者被分为干预组和对照组，分别接受辅酶Q10补充剂或安慰剂。两组患者的手术特征相似。干预组在手术前7天每天接受150毫克辅酶Q10补充剂。对照组接受安慰剂胶囊。比较术后补充前后及CABG术后12小时两组间及组内肌酸激酶同工酶（CK-MB）和肌钙蛋白的血药浓度，以及术后重症监护病房（ICU）住院时间和住院时间等结果。
本研究每组有40名受试者。参与率为97.5%，男性和女性分别占52.5%和47.5%。受试者的平均年龄为58.17±8.55岁。两组在基本变量方面无显著差异。组内比较显示，肌钙蛋白水平随时间显著升高（P<0.001），CK-MB水平也显著升高（P<0.001）。然而，组间比较显示，两组在CK-MB（P = 0.384）和肌钙蛋白（P = 0.115）方面无显著差异。最后，在CK-MB（P = 0.095）和肌钙蛋白（P = 0.198）变量上，未观察到干预与时间之间的相互作用。
术前7天补充辅酶Q10对降低CABG术后的CK-MB和肌钙蛋白无效。
