Department of Anesthesiology, Faculty of Medicine, Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Shahid Bahonar Ave., PO Box 3419759811, Qazvin, Iran.
Department of Anesthesiology, Faculty of Medicine, Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Shahid Bahonar Ave., PO Box 3419759811, Qazvin, Iran.
J Cardiothorac Vasc Anesth. 2022 Oct;36(10):3800-3805. doi: 10.1053/j.jvca.2022.06.003. Epub 2022 Jun 9.
Melatonin has emerged as an anti-inflammatory agent, potent direct free-radical scavenger, and an indirect antioxidant in preventing ischemia-reperfusion injury. This study aimed to evaluate melatonin's effect on cardiac biomarkers after coronary artery bypass grafting (CABG).
A double-blind, randomized placebo-controlled pilot clinical study.
Booali Sina Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.
One hundred patients undergoing elective CABG. The patients were divided randomly into control (C) and melatonin (M) groups (50 patients per group).
The M group received 3 mg of melatonin the night before surgery, 3 mg in the morning, and routine cardiac surgery medications. The C group received 1 placebo tablet rather than melatonin. After surgery, the patients in the M group received 3 mg of melatonin, and the C group received 1 placebo tablet at bedtime until the third day after CABG.
In both groups, creatine kinase-MB (CPK-MB), cardiac troponin I, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) were measured before surgery and on the first, second, and third postoperative days. Serum CPK-MB levels on the second and third day after CABG were significantly lower in the M group than in the C group (p < 0.05). Regarding cardiac troponin I, CRP, and ESR markers, there were no significant changes in serum concentration before surgery and on the first, second, and third days after surgery between the 2 groups (p > 0.05). The mean length of hospitalization in the ICU was lower in the M group (3.4 ± 1.05) compared with the C group (3.96 ± 1.06, p = 0.01).
Melatonin reduced the postoperative level of CPK-MB and the length of hospitalization in the ICU in patients who underwent cardiac surgery.
褪黑素已成为一种抗炎剂，是强有力的直接自由基清除剂和间接抗氧化剂，可预防缺血再灌注损伤。本研究旨在评估褪黑素对冠状动脉旁路移植术（CABG）后心脏生物标志物的影响。
一项双盲、随机安慰剂对照的初步临床研究。
伊朗 Qazvin 医科大学 Boovali Sina 医院。
100 例行 CABG 的患者。患者随机分为对照组（C 组）和褪黑素组（M 组）（每组 50 例）。
M 组患者手术前一晚、早上各接受 3mg 褪黑素，以及常规心脏手术药物治疗。C 组患者接受 1 片安慰剂而非褪黑素。手术后，M 组患者在睡前接受 3mg 褪黑素，C 组患者接受 1 片安慰剂，直至 CABG 后第 3 天。
两组患者均在术前和术后第 1、2、3 天测量肌酸激酶同工酶-MB（CPK-MB）、心肌肌钙蛋白 I、红细胞沉降率（ESR）和 C 反应蛋白（CRP）。与 C 组相比，M 组患者 CABG 后第 2、3 天的血清 CPK-MB 水平明显更低（p<0.05）。关于心肌肌钙蛋白 I、CRP 和 ESR 标志物，两组患者术前和术后第 1、2、3 天的血清浓度均无明显变化（p>0.05）。与 C 组相比，M 组患者 ICU 住院时间更短（M 组：3.4±1.05；C 组：3.96±1.06，p=0.01）。
褪黑素可降低行心脏手术患者的术后 CPK-MB 水平和 ICU 住院时间。
