Mohamed Musab Awad, Eldin Imad Mohamed Taj, Mohammed Abd-Elwahab Hassan, Hassan Hozeifa Mohamed
Department of Pharmacology, Faculty of Pharmacy, University of Gezira, Sudan.
Department of Pharmacology and Toxicology, Medicinal and Aromatic Plant Research Institute, National Center of Research, Sudan.
J Intercult Ethnopharmacol. 2015 Dec 22;5(1):22-6. doi: 10.5455/jice.20151123043218. eCollection 2016 Jan-Feb.
Natural products with therapeutic properties such as plants, minerals, and animal products, for many years, were the main sources of drugs for the treatment of numerous diseases; hence selection of Lawsonia inermis L. (Henna) to study its hepatoprotective activity was considered.
This was an attempt to evaluate the hepatoprotective effect of L. inermis leaves' methanolic extract on carbon tetrachloride (CCl4)-induced hepatotoxicity in rats.
The L. inermis leaves' methanolic extract, which obtained by maceration, was orally administered in doses of 100 mg/kg and 200 mg/kg to the tested animals to assess its effects on serum levels of hepatotoxicity parameters, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), bilirubin, and total proteins along with histopathological liver sections examination, while silymarin (25 mg/kg), a potent hepatoprotective drug, was used as standard control.
The two doses of the plant extract showed dose-dependent hepatoprotective effect, as evident by the significant reduction (P < 0.05) in serum levels of AST, ALT, ALP, and bilirubin along with the improvement in histopathological liver sections compared to CCl4-only treated animals.
As experimentally evident, it could be concluded that this plant material could provide a hepatoprotective effect that could be attributed to its antioxidant properties.
多年来，具有治疗特性的天然产物，如植物、矿物质和动物制品，一直是治疗多种疾病的主要药物来源；因此，选择无刺指甲花（指甲花）来研究其保肝活性。
本研究旨在评估无刺指甲花叶片甲醇提取物对四氯化碳（CCl4）诱导的大鼠肝毒性的保肝作用。
通过浸渍法获得的无刺指甲花叶片甲醇提取物，以100mg/kg和200mg/kg的剂量口服给予受试动物，以评估其对肝毒性参数血清水平、丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、碱性磷酸酶（ALP）、胆红素和总蛋白的影响，同时进行肝组织病理学切片检查，而水飞蓟素（25mg/kg）作为一种有效的保肝药物用作标准对照。
与仅用CCl4处理的动物相比，该植物提取物的两种剂量均显示出剂量依赖性的保肝作用，表现为AST、ALT、ALP和胆红素血清水平显著降低（P<0.05）以及肝组织病理学切片有所改善。
如实验所示，可以得出结论，这种植物材料可以提供保肝作用，这可能归因于其抗氧化特性。
