Xu Ying, Liu Xiang, Sun Xiaohe, Wang Yibing
Department of Nephrology, Shandong Provincial Hospital affiliated to Shandong University , Jinan, Shandong , China.
School of Medicine, Shandong University , Jinan, Shandong , China.
PeerJ. 2016 Mar 29;4:e1859. doi: 10.7717/peerj.1859. eCollection 2016.
Serum uric acid (SUA) level has been proposed to have important connections with chronic kidney disease (CKD), while the impact of SUA level on the natural history of glomerular filtration rate (GFR) decline remains unknown. The present study aims to study the association of the SUA level with the GFR decline in a general population. Two thousand, seven hundred and eighty-nine subjects who visited the Health Checkup Clinic both at 2008 and 2013 were identified. A significant inverse correlation was observed between change in SUA from 2008-2013 (ΔSUA) and change in eGFR (ΔeGFR) during the same period. Multivariate regression analysis of ΔeGFR indicated that the increase in SUA over time were a negative predictor of the change in eGFR. Our result indicates that the decline of eGFR over years is larger in subjects with an increased SUA level, which helps to underline the importance of SUA level management in the context of kidney function preservation.
血清尿酸（SUA）水平被认为与慢性肾脏病（CKD）存在重要关联，而SUA水平对肾小球滤过率（GFR）下降自然病程的影响尚不清楚。本研究旨在探讨一般人群中SUA水平与GFR下降之间的关联。确定了2008年和2013年都前往健康体检诊所就诊的2789名受试者。观察到2008 - 2013年期间SUA的变化（ΔSUA）与同期估算肾小球滤过率（eGFR）的变化（ΔeGFR）之间存在显著负相关。对ΔeGFR进行多变量回归分析表明，SUA随时间的增加是eGFR变化的负预测因子。我们的结果表明，SUA水平升高的受试者多年来eGFR的下降幅度更大，这有助于强调在肾功能保护背景下SUA水平管理的重要性。
