Woo Koan Sik, Hwang In Guk, Kim Hyun Young, Lee Sang Hoon, Jeong Heon Sang
National Institute of Crop Science, Rural Development Administration, Gyeonggi 16616, Korea.
National Academy of Agricultural Science, Rural Development Administration, Jeonbuk 54875, Korea.
Prev Nutr Food Sci. 2016 Mar;21(1):68-72. doi: 10.3746/pnf.2016.21.1.68. Epub 2016 Mar 31.
To examine the possibility of using thiacremonone isolated from high-temperature-high-pressure treated garlic, this study investigated the physiological activities properties. The IC50 values of hydroxyl, superoxide, hydrogen peroxide, and nitric oxide radical scavenging activities of thiacremonone were 92.50, 65.05, 12.60, and 81.53 μg/mL, respectively. On the other hand, the activities of vitamin C were 104.93, 99.43, 42.42, and 122.64 μg/mL, and the activities of butylated hydroxyanisole were 37.22, 68.45, 22.47, and 40.54 μg/mL, respectively. The IC50 value of ACE inhibition activities of thiacremonone and captoprill were 0.265 and 0.036 μg/mL, respectively. The IC50 value of xanthine oxidase inhibition activities of thiacremonone and allopurinol were 39.430 and 9.346 μg/mL, respectively. The IC50 value of tyrosinase inhibition activities of thiacremonone and kojic acid were 101.931 and 65.648 μg/mL, respectively.
为研究使用从高温高压处理的大蒜中分离出的硫代cremonone的可能性，本研究调查了其生理活性特性。硫代cremonone对羟基自由基、超氧阴离子自由基、过氧化氢和一氧化氮自由基的清除活性的IC50值分别为92.50、65.05、12.60和81.53μg/mL。另一方面，维生素C的相应活性分别为104.93、99.43、42.42和122.64μg/mL，丁基羟基茴香醚的活性分别为37.22、68.45、22.47和40.54μg/mL。硫代cremonone和卡托普利对ACE抑制活性的IC50值分别为0.265和0.036μg/mL。硫代cremonone和别嘌呤醇对黄嘌呤氧化酶抑制活性的IC50值分别为39.430和9.346μg/mL。硫代cremonone和曲酸对酪氨酸酶抑制活性的IC50值分别为101.931和65.648μg/mL。
