Guma Sergei, Maglantay Remegio, Lau Ryan, Wieczorek Rosemary, Melamed Jonathan, Deng Fang-Ming, Zhou Ming, Makarov Danil, Lee Peng, Pincus Matthew R, Pei Zhi-Heng
Department of Pathology, York University School of Medicine New York, NY 10010, USA.
Department of Pathology, State University of New York Brooklyn, NY 10010, USA.
Am J Clin Exp Urol. 2016 Jan 28;4(1):12-6. eCollection 2016.
The human papilloma virus (HPV) is a carcinogen known for its strong association with cervical cancers and cervical lesions. It is also known to be associated with a variety of squamous cell carcinomas in other areas, such as the penis, vulva, anus and head and neck. However, the association with urothelial carcinoma remains controversial. Here, we report a case of urothelial carcinoma with squamous differentiation associated with HPV-6/HPV-11.
This is a case of a 70 year old man who presented with nocturia and pressure during urination. During the TURP procedure for what was clinically thought to be benign prostate hyperplasia with pathologic diagnosis as prostate carcinoma, a 2 cm papillary mass was found in the distal penile urethra. The papillary mass was found to be a high grade urothelial carcinoma positive for GATA 3 expression, with focal areas of squamous differentiation. The areas with squamous differentiation demonstrated koilocytic differentiation, which were positive for strong p16 expression. The tumor was found to harbor low risk HPV 6/11 by in situ hybridization.
This study case demonstrates HPV infection with a low risk subtype (HPV 6/11) associated with an urothelial carcinoma with squamous differentiation and condylomatous features.
人乳头瘤病毒（HPV）是一种致癌物，因其与宫颈癌及宫颈病变密切相关而闻名。它还与其他部位的多种鳞状细胞癌有关，如阴茎、外阴、肛门以及头颈部。然而，其与尿路上皮癌的关联仍存在争议。在此，我们报告一例与HPV - 6/HPV - 11相关的伴有鳞状分化的尿路上皮癌病例。
这是一名70岁男性患者，表现为夜尿症和排尿时的压迫感。在经尿道前列腺切除术（TURP）过程中，临床诊断为良性前列腺增生，病理诊断为前列腺癌，术中在阴茎远端尿道发现一个2厘米的乳头状肿物。该乳头状肿物被发现是GATA 3表达阳性的高级别尿路上皮癌，伴有局灶性鳞状分化区域。鳞状分化区域显示挖空细胞分化，p16强表达阳性。通过原位杂交发现肿瘤携带低风险HPV 6/11。
本研究病例表明低风险亚型（HPV 6/11）的HPV感染与伴有鳞状分化和湿疣样特征的尿路上皮癌有关。
