通过免疫黏附试验检测针对自体人白血病细胞的抗体。

Detection of antibody to autologous human leukemia cells by immune adherence assays.

作者信息

Garrett T J, Takahashi T, Clarkson B D, Old L J

出版信息

Proc Natl Acad Sci U S A. 1977 Oct;74(10):4587-90. doi: 10.1073/pnas.74.10.4587.

DOI:10.1073/pnas.74.10.4587

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC431991/

Abstract

The sera of 21 adult patients with acute leukemia were studied for the presence of antibody reacting with surface antigens of autologous leukemia cells. Sequential serum samples were obtained from patients and were tested on cryopreserved leukemia cells in immune adherence assays. Three patients showed autologous serum reactivity and the serum of one of them was analyzed in detail. This antibody reacted with autologous acute lymphocytic leukemia cells but not with autologous cells obtained from peripheral blood, bone marrow, or spleen during clinical remission. In absorption tests, the antigen could not be detected on normal autologous or allogeneic blood lymphocytes, lymphoblastoid lines of T- or B-cell origin, or cells infected with simian sarcoma virus, baboon C-type virus, or Mason-Pfizer virus. Leukemia cells from two other patients with acute lymphocytic leukemia and one patient with acute nonlymphocytic leukemia absorbed specific reactivity. These studies indicate that certain acute leukemia cells express a common antigen that elicits a humoral immune response in the autologous host.

摘要

对21例成年急性白血病患者的血清进行研究，以检测是否存在与自体白血病细胞表面抗原发生反应的抗体。从患者处获取系列血清样本，并在免疫黏附试验中对冻存的白血病细胞进行检测。3例患者显示出自体血清反应性，其中1例患者的血清进行了详细分析。该抗体与自体急性淋巴细胞白血病细胞发生反应，但与临床缓解期从外周血、骨髓或脾脏获取的自体细胞不发生反应。在吸收试验中，在正常自体或同种异体血淋巴细胞、T或B细胞来源的淋巴母细胞系或感染猿猴肉瘤病毒、狒狒C型病毒或梅森- Pfizer病毒的细胞上均未检测到该抗原。另外2例急性淋巴细胞白血病患者和1例急性非淋巴细胞白血病患者的白血病细胞吸收了特异性反应性。这些研究表明，某些急性白血病细胞表达一种共同抗原，可在自体宿主中引发体液免疫反应。

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1

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Proc Natl Acad Sci U S A. 1966 Dec;56(6):1699-704. doi: 10.1073/pnas.56.6.1699.

2

Antigenic modulation. Loss of TL antigen from cells exposed to TL antibody. Study of the phenomenon in vitro.抗原调制。暴露于TL抗体的细胞中TL抗原的丧失。该现象的体外研究。

J Exp Med. 1968 Mar 1;127(3):523-39. doi: 10.1084/jem.127.3.523.

3

Rosette-forming human lymphoid cell lines. I. Establishment and evidence for origin of thymus-derived lymphocytes.形成玫瑰花结的人淋巴细胞系。I. 胸腺衍生淋巴细胞起源的建立及证据。

J Natl Cancer Inst. 1972 Sep;49(3):891-5.

4

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5

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6

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