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用于识别和治疗药物使用的尿液药物检测中的临床与公共卫生考量

Clinical and Public Health Considerations in Urine Drug Testing to Identify and Treat Substance Use.

作者信息

Barthwell Andrea G

机构信息

a Encounter Medical Group , Oak Park , Illinois , USA.

出版信息

Subst Use Misuse. 2016 May 11;51(6):700-10. doi: 10.3109/10826084.2015.1135953. Epub 2016 Apr 12.

DOI:10.3109/10826084.2015.1135953
PMID:27071006
Abstract

BACKGROUND

To expand appropriate use of substance use testing, practitioners must increase their knowledge of the appropriate methodology, scope, and frequency. Yet, there is a current lack of accepted guidelines on clinical testing to identify and treat substance use.

OBJECTIVES

This article (1) conveys the importance of substance use testing as a clinical and public health response to trends of prescription drug abuse and increased access to medical and commercialized marijuana; (2) summarizes central features of the rapidly evolving science and the practice of patient-centered substance use testing in a clinical setting; and (3) provides recommendations that balance costs and benefits and serve as a starting point for appropriate testing to prevent, identify, and treat substance use disorders.

METHODS

The author conducted a search of peer-reviewed and government-supported articles and books in electronic databases and used her own knowledge and clinical experience.

RESULTS

The author makes recommendations for determining the methodology, scope, and frequency of testing in each stage of care based on clinical considerations and methodological factors. Conclusion/Importance: Integrating sensible substance use testing broadly into clinical health care to identify substance use, diagnose substance use disorders, and guide patients into treatment can improve health outcomes and reduce the costs of substance use and addiction. No single testing regimen is suitable for all clinical scenarios; rather, a multitude of options, as discussed herein, can be adapted to meet a patient's unique needs. Ultimately, the practitioner must combine patient-specific information with knowledge of test technologies, capabilities, limitations, and costs.

摘要

背景

为了扩大药物使用检测的合理应用,从业者必须增加他们对适当方法、范围和频率的了解。然而,目前缺乏关于识别和治疗药物使用的临床检测的公认指南。

目的

本文(1)传达了药物使用检测作为对处方药滥用趋势以及医用和商业化大麻获取增加的一种临床和公共卫生应对措施的重要性;(2)总结了在临床环境中快速发展的以患者为中心的药物使用检测科学及实践的核心特征;(3)提供了平衡成本和效益的建议,并作为适当检测以预防、识别和治疗药物使用障碍的起点。

方法

作者在电子数据库中搜索了同行评审和政府支持的文章及书籍,并运用了自己的知识和临床经验。

结果

作者基于临床考量和方法学因素,对护理各阶段检测的方法、范围和频率的确定提出了建议。结论/重要性:将合理的药物使用检测广泛纳入临床医疗保健,以识别药物使用、诊断药物使用障碍并引导患者接受治疗,可改善健康结局并降低药物使用和成瘾的成本。没有单一的检测方案适用于所有临床情况;相反,本文讨论的多种选择可进行调整以满足患者的独特需求。最终,从业者必须将患者特定信息与检测技术、能力、局限性和成本的知识相结合。

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Evaluation of adherence monitoring in buprenorphine treatment: A pilot study using timed drug assays to determine accuracy of testing.评估丁丙诺啡治疗中的药物依从性监测:一项使用时间药物检测来确定检测准确性的试点研究。
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Lacking evidence for the association between frequent urine drug screening and health outcomes of persons on opioid agonist therapy.
缺乏频繁尿液药物筛查与阿片类激动剂治疗者健康结果之间关联的证据。
Int J Drug Policy. 2019 Feb;64:30-33. doi: 10.1016/j.drugpo.2018.08.006. Epub 2018 Dec 12.
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Large Variation in Provincial Guidelines for Urine Drug Screening during Opioid Agonist Treatment in Canada.加拿大阿片类激动剂治疗期间尿液药物筛查省级指南存在很大差异。
Can J Addict. 2018 Jun;9(2):6-9. doi: 10.1097/CXA.0000000000000015.